Endocrine Abstracts

Background: Acetyl-CoA-Carboxylase (ACC1), the rate-limiting enzyme of de novo lipogenesis, plays a critical role in beta cell growth and insulin secretion. In spite of plethora evidence for the role of ACC1 in insulin secretion and beta cells function both in vivo and in vitro, very little is known about how ACC1 activity is regulated in pancreatic beta cells. The aim of the current study was to screen for novel phospho-sites that may regulate ACC1 activity ...

Phosphorus is involved in energy storage, metabolism, nucleic acids, cell membrane function, cell signaling; it is a fundamental constituent of skeleton and teeth. Pi homeostasis is regulated mainly by three hormones, namely parathyroid hormone (PTH), vitamin D and Fibroblast Growth Factor 23 (FGF23). Additionally, sex hormones are known to decrease circulating Pi levels, by reducing renal tubular reabsorption through direct and indirect effects on renal phosphate channels and...

Providing good information, exchanging expertise and stimulating clinical discussions are usually main goals when structuring academic services. Nowadays, especially in large countries with social/economic differences between regions, such as Brazil, telemedicine and telehealth are resources with main strategic importance in a country’s Public Health System. Since its creation, RUTE network (Rede Universitária de Telemedicina, supported by brazilian Ministry of Scien...

The 22q11.2 deletion syndrome is a clinical syndrome caused by a hemizygous deletion in the chromosome 22q11.2. Clinical findings include cardiac defects, characteristic facial features, thymic hypoplasia, cleft palate, hypoparathyroidism, learning difficulties and psychiatric disorders. The importance of chromosome 22 relies on small number of genes located in the long (Q) arm participating in the development of the body plan, including the pharyngeal arches during the embryo...

Significant advancements have been made in the last century regarding the neuronal control of feeding behavior and energy expenditure. The effects and mechanism of action of various peripheral metabolic signals on the brain have become clearer. Molecular and genetic tools for visualizing and manipulating individual components of brain homeostatic systems in combination with neuroanatomical, electrophysiological, behavioral and pharmacological techniques have begun to elucidate...

The prevalence of sarcopenic obesity (SO) is increasing worldwide, posing important challenges to public health and national health care system, especially during the COVID pandemic. In subjects with SO, it is essential to reduce body weight preserving lean mass, in order to avoid a worsening of muscle function. Lifestyle modification with adequate nutrition and proper physical activity is essential to counteract SO progression. In accordance with the Position Statement of the...

Osteoporosis is a chronic condition requiring long-term treatment; sequential treatment regimens with different agents represents an option aimed to increase bone mineral density (BMD) and then to maintain it. The loss of BMD occurring after withdrawal of teriparatide (TPT) can be prevented by bisphosphonates (BPs). Among BPs, data about the efficacy of zoledronic acid (ZOL) after TPT treatment are scanty. Here, we contribute to this topic providing data derived from the real-...

Osteoporosis management increased determination of serum calcium (Ca) levels, and detection of hypercalcemia in the set of out patients. Serum phosphate (P) levels are less frequently measured in osteometabolic patients. Primary hyperparathyroidism (PHPT) is the most common cause of hypophosphatemia. However, hypophosphatemia receives poor attention during the PHPT diagnostic work up, and also data in literature are scanty. We retrospectively reviewed the clinical records from...

The expression of key molecules involved in fundamental cell processes and epigenetic gene expression modulation is altered in human parathyroid tumours, due to gene mutations, loss of heterozygosity, aberrant gene promoter methylation, DNA copy number variations. We performed a gene profiling of 26 parathyroid tumorigenesis-related genes in a series of 32 sporadic parathyroid adenomas (PAds) surgically removed from patients with primary hyperparathyroidism, with the aim to de...

Chronic hypophosphatemia (HP) can be observed among patients (pts) evaluated and treated for osteoporosis, but its prevalence and management are poorly defined. In this study we analyze prevalence, clinical features and diagnostic workup for chronic HP among pts attending a third-level osteoporosis office. Chronic HP was defined as serum phosphate levels persistently < 2.7 mg/dl over a period ≥ 6 months. Tubular reabsorption of phosphate (TRP) was measured and, in pr...