Endocrine Abstracts

Thyroid disease is common among the population, and the prevalence increases with age. In patients with type 1 diabetes mellitus (T1DM) the risk of thyroid dysfunction and thyroid autoimmunity is increased. The aim of this study was to investigate the relationship between thyroid function and T1DM duration. There were evaluated 110 patients (71 women and 39 men) with T1DM between 2013 and 2015 and were appreciated antibodies against thyroid peroxidase (ATPO) (normal values...

Background: Graves disease is a resurgent autoimmune condition that is known to occur during treatment and immune reconstitution in HIV, and it is one of the commonly diagnosed endocrinopathies in these patients. Graves orbitopathy, on the other hand, is a situation that occurs less frequently. We report the clinical features and manifestations of thyroid-associated orbitopathy in a case of an HIV patient with Graves disease.Case Presentation: A 48-year-...

Hypothyroidism is one of the most common endocrine disorders. The long-time debatable question is whether patients with subclinical hypothyroidism (SH) should be treated with levothyroxine. Data are contradictory and treatment decision depends on several factors: TSH level, anti-TPO level, age, presence of symptoms etc. Hypothyroidism is associated with cardiovascular disease. Even a minor increase in C-reactive protein (CRP) is considered a cardiovascular risk, therefore evid...

Introduction: Osteocalcin is a bone-specific hormone also involved in regulation of glucose and fat mass metabolism. It regulates energy expenditure by acting on adipocytes and pancreatic islet cells. The aim of the present study was to examine the relation between serum osteocalcin and glucose metabolism in young women with obesity. Material and methods: A total of 66 healthy women were included in the analysis. Data on body mass index (BMI), waist circ...

Here we report the case of a woman with first presentation of Addison disease in pregnancy that went undiagnosed until postpartum period. She gave birth to a healthy child by vaginal delivery at 40 weeks of pregnancy. Our patient is a 31 years pregnant woman with unremarkable medical or familial history. At 8 weeks of pregnancy she was complaining of nausea, vomiting, loss of appetite and fatigue, leading to hospitalization. The physical examination revealed a blood pressure o...

Background and Aim: Diabetes mellitus (DM) represents a substantial burden on health care systems, being the 8th leading cause of death and disability in the world in 2019, associated with long-term microvascular (neuropathy, retinopathy, and nephropathy) and macrovascular (ischemic heart disease, stroke, peripheral vascular disease) complications. DM comorbidities lead to a substantial decrease in quality of life, as well as important socio-economic consequences. In 2022, the...

Background: Hashimoto thyroiditis is the most common autoimmune disease, with a marked prevalence in women. Occasionally, it may be associated with renal disease. Most described renal lesion in patients with autoimmune thyroiditis is membranous glomerulonephritis.Case: A 32 years old Caucasian man consulted the endocrinologist with a 4 months history of progressive fatigue, headache, arthralgia, dryness of skin and increased weight of approximately 10 kg...

Disorders of the thyroid gland in the Republic of Moldova rank second among endocrine diseases (after diabetes mellitus), hypothyroidism being one of the most widespread diseases. In communities, the prevalence of overt hypothyroidism is from 0.1 to 2 percent, and that of subclinical hypothyroidism is up to 10 percent of adults (increasing even more in women, and with advanced age). Regarding the prevalence of hypothyroidism in the Republic of Moldova, it is necessary to menti...

Introduction: Aberrant expression of serotonin receptors has been described to be involved in the pathophysiology of both aldosterone-producing and cortisol-producing adrenal adenomas.Case report: A 46-year-old woman was referred for evaluation of severe hypertension associated with hypokalaemia. Primary aldosteronism with concurrent subclinical Cushing’s syndrome was diagnosed. A CT-scan identified a lesion of 4 cm in the right adrenal gland and a ...

Aims: To determine the role of intima–media thickness (IMT) of internal carotid artery (ICA) in the diagnosis of coronary atherosclerosis in patients with type 2 diabetes (T2D) and silent ischaemia (SI).Methods: We provide a retrospective analysis of 60 cases of patients with T2D (24 men, age 60.5±4.7 years), history of diabetes – 4.7±0.5 years. SI was diagnosed by comparing complaints, anamnesis, ECG data and daily ECG monitoring. Al...