Endocrine Abstracts

Ghrelin is an endogenous ligand of the GH secretagogue receptor. The influence of ghrelin on different organs has been studied recently e.g. in the regulation of pituitary hormone release, regulation of energy homeostasis, glucose metabolism and insulin secretion, cell proliferation and reproductive function.The etiology of PCOS has not been firmly explained, althought several pathways have been implicated – the regulatory pathways of steroid hormon...

Captive breeding of wild animals is a first step of domestication. The process is accompanied by a number of adaptations to captive conditions, which resulting in behaviour, physiological and morphological changes. One of morphological consequences of domestication is a coat-colour mutation named Star (S) that is characterised by some unpigmented areas on the skin. The dominant mutation was first revealed in farm-bred populations of silver foxes, but the highest frequency of t...

Background: Gestational diabetes mellitus (GDM) is characterized by increased insulin resistance. There is a link between perinatal depression or anxiety and GDM. Mental health problems are associated with higher insulin resistance and could explain the underlying association between GDM and depression or anxiety symptoms. We investigated the trajectories and associations between symptoms of mental health and well-being with insulin resistance and metabolic health in women wit...

Objective: Assess the effectiveness of complex treatment of obesity with the use of orlistat (intestinal lipase inhibitor) on the knee OA (KOA) and the dynamics of cytokines (CRP, IL-6, TNF-α) depending on the degree of weight loss.Methods: 50 female patients (45–65 y.o.) with Kellgren-Lawrence stage II-III KOA and obesity (BMI > 30 kg/m²). Patients in Group 1 (n = 25) took 120 mg of orlistat 3 times a day in co...

Brain tumors are on the 3rd place in terms of growth rates of incidence among oncological diseases. By virtue of the improvement of neurosurgical treatment methods, with the use of modern chemotherapy and radiation therapy, the survival of patients with benign and malignant brain tumors is increasing. A significant proportion of patients with such tumors are young people of reproductive age who are interested in maintaining their fertility. Neurosurgical removal of tumors, whi...

Objective: Prospective study of medical treatment effect in newly diagnosed patients with large and giant prolactinomas.Patients and methods: The study group included 45 patients with large prolactinomas (tumors more 3,6 cm) and 23 patients with giant prolactinomas (tumors more than 6 cm); from them 8 mainly cystic tumors. The treatment period was 3–24 month (mean 6). Serum prolactin level before treatment ranged between 12 990 and 1 038 000 mU/l (m...

Background and aims: The aim of this study was to assess the effects of docosahexaenoic (DHA) and eicosapentaenoic acid (EPA) on the heart rate variability (HRV), some biochemical parameters in patients (pts) with Type 2 diabetes mellitus and cardiovascular aunonomic neuropathy (CAN).Materials and methods: 39 pts with CAN (54±5 yrs) were allocated in two groups: A (n=26) were receiving capsules of fish oil every day (2.0 g EPA, 2.0 g DHA and ...

Background and aims: The present study has examined the effect of α-lipoic acid (ALA) and nicotinamide (NA) on the heart rate variability (HRV), superoxide dismutase (SOD), gluthation peroxidase (GPO), catalase activities, reduced gluthatione (GSH), malondialdegide (MDA) contents in the RBCs’ in Type 2 diabetic patients (T2DM) with cardiovascular autonomic neuropathy (CAN).Materials and methods: 59 patients with T2DM and CAN (59.3±7.9 year...

Craniopharyngiomas (CF) - a benign tumor of the embryologic origin. The surgical method of treatment is the basic.Objective: to estimate incidence of hypogonatropic hypogonadism before and after surgical treatment of CF at different topographical variations, and after the preservation of the pituitary stalk. Methods: The research involved 79 patients older than 18 years (41 women and 38 men) with a mean age - 40 [17; 69] with a ver...

Background: CYP24A1 gene encodes the enzyme vitamin D 24-hydroxylase, which converts active vitamin D to inactive metabolites. More than 20 currently described, usually biallelic pathogenic variants of this gene are responsible for idiopathic infantile hypercalcemia manifested typically in childhood (often in newborns) with hypercalcemia, hypercalciuria and nephrocalcinosis. However, a few patients (mostly with monoallelic heterozygous pathogenic variant) can develop mild symp...