Endocrine Abstracts

AimObesity was shown to be related to global cognitive decline, being especially altered the executive function and the information processing speed. Additionally, sarcopenic obesity (SO) was associated independently with a deterioration in global cognition, executive function, information processing speed, global memory and cerebral atrophy in patients > 65 years. However, at present there is no data regarding the role of sarcopenia in the cognitive...

Normocalcemic primary hyperparathyroidism (nPHPT) is still a poorly understood entity, characterized by increased circulating parathormone (PTH) and normal total and ionic calcium, excluding secondary causes.Aim: To characterize the cases of nPHPT detected for a whole year from laboratory records of PTH in a tertiary referral centre, with the purpose of assessing a preliminary estimation and describing their main features.Material ...

Aim: Gestational diabetes (GDM) has been associated with an increased risk ofneurocognitive outcomes in offspring such as attention deficit/hyperactive disorders (ADHD) and autism spectrum disorders (ASD). However GDM-related comorbidities (obesity or excessive weight gain –EWG-) in this setting have been scarcely studied. So, the aim of our study was to estimate the risk of ADHD and ASD in this population.Material and Methods: Cohort study. Single...

Objective: To study the association between the state of iodine nutrition, and the risk of total and cause mortality in a representative sample of the Spanish adult population.Design: Longitudinal observational study to estimate mortality risk according to urinary iodine (UI) concentrations using a sample of 4370 subjects >18 years representative of the Spanish adult population participating in the national study [email protected] (2008–2010). We used ...

Introduction: Pheocrhomocytomas are rare tumors, principally benigns, and with high risk of morbimortality because of secretion of big amountos of catecholamines. They are an unfrequently cause of arterial hypertension in pediatric age but physicians must remember it because they can be diagnosed, treated and cured in a proper way.Objectives: To evalue the cases reports of pediatric pheochromocytoma found in our area, to analyze the differences in diagno...

IntroductionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has generate a pandemic disease around the world. It has been documented that diabetes mellitus (DM) acts as a risk factor among people hospitalized with coronavirus disease (COVID-19). The objective of this study is to test if DM may unfavorably influence the outcome of COVID-19.MethodsData from Hospital Universitario Central ...

Introduction: The metabolic risk associated with air pollution could vary according to the specific pollution levels of each area, as well as factors related to lifestyle (diet, activity physical, socioeconomic status, tobacco), other exposures, comorbidities etc.. and has been insufficiently evaluated in our country.Objective: To study the association between long term exposure to air pollution (measured as PM concentrations) and the incidence of hypert...

Introduction Angiopoietin-like 4 protein (ANGPTL-4) is importantly produced in adipose tissue, mediates the inhibition of lipoprotein-lipase and has been recently related with the risk of atherosclerosis and type 2 diabetes (T2D). Bariatric surgery has demonstrated improvements in lipid profile, T2D and cardiovascular risk. But information about ANGPTL-4 circulating levels in severe obesity and after bariatric surgery is scarce.Obj...

The introduction of PCSK9 inhibitors has changed the paradigm of dyslipidemia treatment. These monoclonal antibodies produce an incremental LDL reduction of about 60% add-on current therapy. Achieving LDL concentrations below 40 mg/dl is usual. The recent publication on the effect of very low LDL concentrations on atherosclerotic plaque burden (Glagov study) and on cardiovascular outcomes (Fourier and Spire) show the impact of this therapy in cardiovascular prevention. In the ...

IntroductionDiabetes, a metabolic disorder characterized by abnormal blood glucose levels, is a serious chronic disease that implies an important public health problem. Being Insulin the main hormone for modulating blood glucose levels, subcutaneous injections are the main way for its administration in the diabetes treatment. However, this way of administration can lead to poor patient compliance, apart from several side-effects. Although other ways of a...