Endocrine Abstracts

Background and aims: Many obese patients with type 2 diabetes mellitus (T2DM) are not adequatly controlled with oral antidiabetic therapy (OAD), even with combination between metformin and sulfonylurea (SU). When OADs no longer maintain good glycaemic control in obese T2DM, it is necessary to add insulin therapy. The aim of this study is to compare the effect of adding premixed insulin aspart 30(BIAsp30) vs. premixed human insulin 30/70 (BHI30) to support metformin therapy in ...

Background and aims: Metformin is the drug of first choice in obese patients with type 2 diabetes (T2DM), but in some patients it is not possible to achieve good glycaemic control by using metformin only. Starting from a fact that T2DM is a heterogeneous disorder due to the interaction of impaired early insulin secretion and peripheral insulin resistance, the aim of the present study was to evaluate and compare the efficacy of repaglinide vs. glimepirid on glycaemic control of...

The neuropeptide PACAP regulates numerous endocrine functions such as growth, metabolism and reproduction. In pituitary gonadotrophs, PACAP acts as a potent stimulator of gonadotrophin gene transcription and secretion, and potentiates the stimulatory effects of GnRH. We have examined the combinatorial effects of PACAP with GnRH or other activators of GnRH-signalling pathways in mouse αT3-1 gonadotroph and rat PC12 phaeochromocytoma cells. αT3-1 cells transiently tran...

Objectives: The value of ultrasound in functional disorders can be significant. That is why the question arises on the use of ultrasound examination of thyroid gland and its echogenity as a screening method in early detection of disfunctions, primarily subclinical and clinical forms of hypothyreosis.Methods: Testing included 328 patients. All examinees underwent ultrasound examination of thyroid gland, the blood was taken for determination of FT4</s...

Relationship of body weight and blood pressure is very complex and still incompletely explained. Obesity, especially visceral, is one of the strongest predictors of arterial hypertension. Hypertension is six times higher in obese than in lean people, with its prevalence increases with an increase in BMI progressively. The mechanisms underlying hypertension in obese are not fully defined. The aim of this research was to determine the influence of various parameters on blood pre...

Introduction: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy (80%), while primary thyroid lymphomas (PTL) occur in only 0.6–5% of cases. A significant number of PTCs, as well as PTLs, arise in the setting of Hashimoto’s thyroiditis (HT), however the simultaneous occurrence of these two malignancies is extremely rare.Case report: We present a 34-year-old female patient with thyroid MALT lymphoma and coexisting papillary ...

C reactive protein is a sensitive marker of subclinical inflammation. C-reactive protein is associated with obesity, diabetes mellitus and increased cardiovascular risk. The mechanism of elevated CRP levels could have connections with insulin resistance. Inflammation seems to have significant role in pathogenesis of diabetes and cardiovascular disease. The aim of this study is to show that the subjects with greater insulin resistance, measured by HOMA-IR have higher levels of ...

Fat tissue is highly active tissue, both metabolically and as endocrine tissue, which produced large number of bioactive peptides, known as adipocitokines. They seem to contribute in pathogenesis of obesity, insulin resistance, diabetes mellitus type 2, hypertension, hyperlipidemia, and vascular disease. Adipocitokines and low grade inflammation could be connection between obesity and coexisting diseases. This is the reason we believe that body weight reduction could have posi...

Objectives: It has been reported that metformin administration lowered TSH levels in patients with type 2 diabetes mellitus and hypothyreosis. The aim of the study was to investigate effect of metformin on TSH levels in type 2 diabetic patients with primary hypothyroidism and also in patient with type 2 diabetes mellitus only.Methods: We included in our study 9 type 2 diabetic patients with primary hypothyroidism on stable l-thyroxine replacement doses a...

Objectives: There are reports which suggests that TSH levels are independetly associated with components of metabolic syndrome. The aim of this study was to investigate the relatinship between thyroid stimulating hormone (TSH) and metabolic syndrome (MetS) in owerweight and obese euthyroid subjects.Methods: In 80 euthyroid owerweight and obese subjects, 44 women and 36 man, fasting blood semples were analyzed for glucose, triglycerides and HDL and estima...