Endocrine Abstracts

Introduction: Hypokalaemic periodic paralysis is a medical emergency when patients present with acute onset paraparesis usually noticed in the mornings secondary to low serum potassium levels with a prevalence of 1 in100,000. The symptoms resolve promptly with correction of potassium. The patient experiences motor symptoms while the sensation is preserved and can be differentiated from acute inflammatory demyelinating polyneuropathy with preserved ocular, bulbar or respiratory...

Background: Ischemic colitis (IC) is a disorder characterized by a decrease in blood flow of the large intestine. Many factors can contribute to decreased blood flow in the arteries supplying the large intestine, such as nonocclusive causes like hypertension and atherosclerosis and occlusive causes like embolism from myocardial infarction. With Ischemic colitis’s high mortality rate and its association with many cardiovascular diseases, it’s important to understand t...

Background: Ischemic colitis (IC) is a disorder characterized by a decrease in blood flow of the large intestine. Many factors can contribute to decreased blood flow in the arteries supplying the large intestine, such as nonocclusive causes like hypertension and atherosclerosis and occlusive causes like embolism from myocardial infarction. With Ischemic colitis’s high mortality rate and its association with many cardiovascular diseases, it’s important to understand c...

Case History: We report the case of a 25-year-old Asian male who presented to our hospital with recurrent episodes of abdominal pain complicated by significant Hyponatremia. Initial admission was in November 2021 followed by March, 2022 with similar symptoms. He remained under surgical care during both admissions. For his severe hyponatremia, an urgent Endocrine input was sought. The patient was not on any medications that could be implicated in his biochemical picture and his...

Introduction: 46,XX disorder of sexual development (DSD) is a rare cause of sex reversal. Only a few hundred cases have been described. The clinical spectrum can be divided into 3 groups of males according to genital appearance: normal male, atypical variants such as hypospadias or cryptorchidism, and those with both male and female genitalia.Subcategories of 46,XX DSD include ovotesticular DSD, which is characterised by the presence of both testicular a...

Background: Histoplasmosis is an opportunistic fungal infection that commonly affects immunocompromised individuals. Histoplasmosis may be asymptomatic or may present with progressive systemic manifestations (pulmonary or disseminated). We present a case of a 76 year old immunocompetent man presented to hospital with 8 weeks history of general malaise and lethargy, intermittent night sweats, a productive cough, weight loss of 2.5 stones in two months and low grade fever. He ha...

A 40 years old man with a diagnosis of Adrenoleukodystrophy (ALD) was referred for evaluation of symptoms suggestive of hypogonadism. He had a past medical history of ALD associated adrenal insufficiency and osteoporosis. He took regular hydrocortisone and a trial medication, MD1003.Following review, post clinic blood tests revealed a testosterone 24.5 nmol/l (7.6–31.4), LH 8.8 IU/l (1.7–8.6) and FSH 1.5 IU/l (1.5–12.4). Thyroid function t...

A 79-year-old female patient, with a background history of hypertension and ischaemic heart disease was brought by ambulance to hospital with near collapse episode associated with capillary blood glucose (CBG) of 2.1 mmol/l. Her regular medications include Ramipril, clopidogrel and atorvastatin. She had no history of diabetes. While inpatient, it was observed that majority of low capillary blood glucose readings (CBG) were late night or early mornings. At venous glucose of 1.9...

Background: Adult spontaneous hypoglycaemia in non-diabetic patients is not a diagnosis per se but a manifestation of a disease and is often a diagnostic challenge. Although rare, it’s important to exclude endogenous hyperinsulinemia, because treatment can be curative. The aim of our audit was to assess the usefulness of various investigations done for spontaneous hypoglycaemia in diagnosing Insulinoma.Methods: Data on 98 non-diabetic patie...

Aim: Bariatric surgery can provide significant weight loss but a complete resolution obstructive sleep apnoea (OSA) cannot be predicted. The aim of our audit was to assess the prevalence of OSA in bariatric clinics and outcomes after malabsorptive bariatric surgery.Methods: Retrospective observational analysis was performed on patients who had undergone bariatric surgery (laparoscopic gastric bypass and sleeve gastrectomy) and completed a minimum of 6 mo...