Endocrine Abstracts

Introduction: Opioid system activity was found disturbed in several reward circuit areas in restrictive anorexia nervosa (AN) patients but also surprisingly at the pituitary level. However, the potential role of this specific abnormality of pituitary in AN physiopathology remains unclear or unknown.Objectives: The first aim was to find the exact pituitary location (posterior and/or anterior) of this disturbed opioid activity and then to study the link be...

Objectives: Cardiovascular disease encountered the leading cause of death in thyroid cancer survivals exceeding death by cancer itself. Etiological factors are the therapy used and the duration of exposure to this it, the diagnosis of cancer itself, or the factors that led to this cancer. We aim to evaluate cardiometabolic risk factors in an Algerian cohort of thyroid cancer survivals.Methods: The study includes a cohort of patients followed in the thyro...

Introduction: Thyroid cancer (TC) in adolescents and adults (AYA) is defined as thyroid cancer diagnosed among those aged between 15-39 years. It is the fifth most common cancer in AYAs, and its incidence is increasing. Compared with older adult patients, the AYA with TC has a higher prevalence of node metastasis which represents a risk factor for recurrence.Aim: To describe the characteristics of thyroid carcinoma with confirmed nodal metastases at the ...

Thyroid disorders are common among women of childbearing years. However, the diagnosis of thyroid disorders during pregnancy is confounded by the normal alteration in thyroid physiology. Serum TSH levels decrease at the end of the first trimester, mirroring the increase in serum hCG levels; hCG is thyrotropic and causes a slight increase in serum free T4 concentrations. With the drop in serum hCG as pregnancy progresses, serum free T4 levels decline and may decrease below the ...

Effects of paint thinner inhalation on serum testosterone synthesis and secretion were investigated in the male rat. A control group inhaled normal air ventilation. The remaining animals were divided into three groups and exposed to paint thinner in a glassy cage for 15 and 30 days. A group of animals was allowed to recover for 15 day after 30 days of exposure. Toluene concentration (the largest constituent in thinner, 66%) was set at 1500 ppm in the inhalation air. At the end...

Several instances of RNA-mediated inheritance of phenotypic variation have been reported, among them metabolic disorders. We and others have observed that microinjection into naive fertilized mouse eggs of total sperm RNAs of obese and diabetic males maintained on high-fat diet induce the same pathological variation in the offspring. A role of noncoding RNAs is currently the prevailing hypothesis.The sperm RNA content is complex. It depends on environmen...

In the healthy liver, GH signals through multiple pathways to modulate hepatic function, with JAK2/STAT5b required to maintain circulating IGF1 levels. It has been previously reported that mice with developmental knockout of hepatocyte GHR, JAK2 or STAT5 develop steatosis associated with glucose intolerance, systemic insulin resistance and white adipose tissue (WAT) lipolysis. These changes are thought to be secondary to increased circulating GH, due to loss of IGF1 negative f...

Manuel Tena-Sempere, Spain AbstractThe European Journal of Endocrinology Prize is awarded to a candidate who has significantly contributed to the advancement of the knowledge in the field of endocrinology through publication. This year's recipient is Professor Manuel Tena-Sempere. The prize will be presented as part of the ECE 2011 opening ceremony where Prof. Tena-Sempere will deliver his lectu...

Adrenal insufficiency, characterised by inadequate cortisol production, significantly impacts quality of life and overall health. Current treatment primarily involves hydrocortisone replacement. However, dosing challenges and risk of adverse cardiovascular complications persist with this therapy. Consequently, there is a pressing need for safer glucocorticoid replacement options to mitigate the cardiometabolic toxicity, while effectively managing adrenal insufficiency. Prelimi...

The ‘Nuclear Receptor (NR) Super-family’ is a group of ligand modulated transcription factors with 48 members presently identified in human genome. NRs regulate most of the physiological processes of the body ranging from metabolism to reproduction. Retinoid X Receptor (RXR) is one of the important members of this NR superfamily. It serves as a heterodimeric partner of several other members of this superfamily including two major xenobiotic nuclear receptors i.e. Pre...