Endocrine Abstracts

Background: Neuroendocrine cancers arise in the endocrine cells localized throughout the body. Most are found in the Gastroenteropancreatic (GEP) system pancreas, stomach, and small and large intestines. They are heterogenous in their etiology, morphology, and phenotypes. Due to late diagnosis and low prevalence, clinical specimens are limited for research. Thus, preclinical models are pivotal for the understanding of this disease. This study focuses on establishing a novel pa...

Introduction: Transsexuality is defined as discordance between one’s assigned sex at birth and that individual’s gender identity. Hormonal, anatomical, legal and psychosocial adaptations are present in most cases. Following recent changes to the Spanish legal framework, modifications have instaured to the model of attention for transsexual people in Andalusia. The aim of this study was to evaluate healthcare demand evolution in Trans People Attention Unit of Puerta...

Introduction: The use of iSGLT2 continues to be controversial in diabetic patients with peripheral arterial disease.Objectives: Assess the metabolic effect and the risk of amputations of iSGLT2 in diabetic patients cared for in the Multidisciplinary Diabetic Foot Unit (MDFU) compared to a control group.Material and Methods: A retrospective observational study where patients attended at the MDFU from December 2017 to January 2020 we...

Introduction and objectivesThyroid cancer treatment tends to be individualized based on risk stratification and increasingly less aggressive for low-risk tumors, as recent studies have shown that low doses of I-131 are just as effective than higher doses with excellent remission rates. The objective of our study was to evaluate the response after 1 year of treatment with 30 mCi of I-131 in patients with differentiated thyroid cancer.<p class="abstext...

Introduction: ALS is a neurodegenerative disease with a high prevalence of malnutrition. Nutritional diagnosis is important because of its prognostic implication.Objective: To determine the clinical and morphofunctional characteristics in a series of patients with ALS.Materials and methods: Cross-sectional descriptive study of patients seen at the multidisciplinary ALS clinic of the Hospital Puerta del Mar (Cádiz).<p class...

IntroductionVitamin D deficiency is associated with higher risk of COVID-19, and type 2 diabetic patients are a vulnerable group. We described an alarming rate of vitamin D deficiency (81.0% < 30 ng/ml plasma calcifediol) in unsupplemented type 2 diabetes patients during the 2020 spring lockdown in Northern Gran Canaria. During the winter period (December 2020 to February 2021) some restrictions for social gatherings and a nightly curfew have been en...

IntroductionThe SARS-Coronavirus-2 pandemic affects 248 469 people with 28 341 deaths in Spain as of June 28, 2020. Severe infection is more prevalent in patients with advanced ages, cardiovascular risk factors (CVRF) and chronic diseases (diabetes mellitus, cardiovascular disease and asthma). Having diabetes implies vulnerability to serious complications and death from coronavirus; although, not all diabetics have the same level of risk. The oldest is p...

Objetives: To analyze the profile of patients referred from Primary Care (PC) to Outpatient Diabetes Center (ODC), as well as the evolution of self-assessment measured by Chronic Care Model IEMAC (Instrument for the Evaluation of Attention Chronicity Models) tool after implementation of a coordinated Task Force between Primary Care and Endocrinology Unit.Methods: The working group of the Advanced Diabetes Center in Cádiz-San Fernando Sanitary Area w...

Introduction: (Anti-TNF-α) therapy is widely used for the treatment of inflammatory diseases. The most frequent adverse events induced by anti-TNF-α therapy are infections and malignancies. However, reports of paradoxical sarcoidosis-like reactions are on the rise in patients receiving anti-TNF-α.Clinical case: A 61-year old woman, with a medical history of sero-positive rheumatoid arthritis on Adalimumab treatment (anti-TNF-α), was r...

Background: Brown adipose tissue (BAT) thermogenesis offers an appealing prospect to combat obesity. Obesity is characterised by a state of chronic inflammation in adipose tissue mediated by the secretion of a range of inflammatory-cytokines. Our previous work has highlighted that a gut-derived inflammatory agent, lipopolysaccharide (LPS), reduces brown adipocyte activity, insulin sensitivity and mitochondrial-function and is increased with obesity and type 2 diabetes mellitus...