Endocrine Abstracts

In clinical trials, the SGLT2 inhibitor Canagliflozin inhibits renal reabsorption of glucose, increases its excretion and reduces hyperglycaemia in patients with type 2 diabetes mellitus (T2DM). The increase in glucosuria and diuresis produced, results in a reduction in weight and blood pressure (BP). Moreover, It may cause genital and urinary tract infections. However, does Canagliflozin behave in the same way in routine clinical practice?Objective: To ...

Primary generalized glucocorticoid resistance or Chrousos syndrome is a rare disorder, which affects all tissues expressing the human glucocorticoid receptor. It has been defined by an absence of overt Cushing’s syndrome (CS) signs (no skin weakness, muscle atrophy, or osteoporosis) associated with biological hypercortisolism consisting of high urinary free cortisol (UFC) and an absence of negative feedback loop of cortisol on HPA, defined as 8-AM cortisol level >50 n...

Introduction: There are a few hypothyroid patients who are refractory to standard thyroid hormone replacement treatment and require unexpectedly high doses of levothyroxine. In addition to clinical situations where hypothyroid patients are non-compliant (pseudomalbsortion), or where there is the possibility of excipient-induced disease exacerbation, therapeutic failure may be due to impaired absorption of the administered drug. The common approach to managing patients is to es...

Mesonephric adenocarcinoma (MA) is an uncommon gynecologic tumor that are thought to arise from embryonal remnants of the mesonephric ducts, also known as Wolffian ducts. Mesonephric-like adenocarcinoma (MLA), despite absence of Wolffian origin, have similar morphology and immunophenotype and exhibit molecular aberrations like MA. These tumors are generally negative for estrogen and progesterone receptor.Case Report: An 83-year-old Spanish female was ref...

Background: Primary bilateral bilateral macronodular adrenal hyperplasia is a cause of Cushing’s syndrome. It is characterised by a large enlargement of the adrenal glands at the expense of multiple non-pigmented nodules. There is inefficient steroidogenesis.Summary of the case: A 58-year-old woman with a history of extreme obesity, type 2 diabetes mellitus, hypertension and dyslipidaemia was admitted to our hospital for cellulitis and anaemia secon...

Introduction: Cinacalcet is a positive allosteric modulator of the calcium sensing receptor successfully used to decrease serum calcium in primary hyperparathyroidism (pHPT) patients in the short-term, but long-term data are scarce. In this single-centre retrospective analysis, we investigated the efficacy and safety of cinacalcet in pHPT patients who received more than 5 years of treatment.Methods: Statistical analysis was performed using free online so...

Cardiovascular disease (CVD) is more prevalent in patients with chronic kidney disease (CKD) and Diabetes mellitus (DM) than in the general population. Microparticles (MPs) released during cell activation and/or apoptosis could be biomarkers of CVD. These MPs, which show vascular damage, are named according to the injured cell, as endothelial (EMPs) or platelet (PMPs).AimAssess the MPs plasma concentration in diabetic pati...

ObjectiveThe aim of the study was to evaluate the overall malignancy rate on final histopathology in nodules with Bethesda III or IV surgically excised and review the ultrasound and cytological features givenMaterial and methodsIs a retrospective analysis of patients referred to our outpatient clinical of endocrinology after thyroid surgery with a previous thyroid nodule FNA cytology in Bethesda III or IV cat...

Introduction: Terlipressin is a non-selective vasopressin analogue used in patients with decompensated cirrhosis, gastrointestinal haemorrhage or hepatorenal syndrome. It directly binds to V1 receptors improving circulatory volume by causing splanchnic vasoconstriction and portal hypertension inhibition, and has a full V2 receptor agonism in the collecting duct. In consequence, it increases reabsorption of water and can lead to a decrease in plasma osmolality and hyponatremia....

Introduction: Ketosis-prone diabetes or Flatbush diabetes has been recognized as a clinical entity since 1984. Is characterized by diabetic ketosis or ketoacidosis occurring soon after the onset of hyperglycemic syntoms (usually poyiuria, polydipsia and weight loss are present for less than 4 weeks). Unlike the insulin dependence seen in type 1 diabetes, after a few weeks (usually 2 to 12 weeks), insulin requeriments decrease, and approximately 70% of patients achieve remissio...