Endocrine Abstracts

Primary hyperparathyroidism is the third most common endocrine disorder, caused, in the majority of cases, by a single parathyroid adenoma and rarely by multigland adenoma or parathyroid carcinoma. Giant parathyroid adenomas, defined as larger than 3 g, represent an uncommon cause of primary hyperparathyroidism, with only a few cases described in the literature. We present the case of a 47 years old female who presented with a significant, unpainful, left cervical mass associa...

Context: Childhood gender dysphoria, when not attenuating after the onset of puberty, is very likely to persist. The aim of puberty suppressing therapy in gender dysphoric adolescents is increasingly shifting from ‘buying time to reflect on the diagnosis’ towards ‘avoiding the development of secondary sexual characteristics while awaiting eligibility for cross-sex hormones’. Various treatment regimens are available to suppress or decrease the effects of end...

Men and women who have AIS face a number of challenges. Based on research insights from the past two decades, management of this pleiotropic condition during childhood has totally changed. In this presentation, we will update endocrinologists who provide care for adults living with AIS about these changes, as they will, after transition, need to further counsel their patients and coordinate multidisciplinary care and surveillance of retained gonads in adulthood. Girls with com...

The incidence of obesity has dramatically increased, not only in industrialized societies but also in developing countries. Since male fertility shows a parallel decrease, obesity should be considered as possible etiology of male subfertility.Studies exploring this possible association report that obesity may affect fertility by different mechanisms that include: abnormal reproductive hormonal milieu, increased release of adipokines and adipose-derived h...

Objective: Agranulocytosis to the antithyroid drugs is a rare adverse drug effect exposure to potentially lethal infections. It is a public health problem with hyperthyroidism in nearly 1% of the French population. However, many uncertainties remain in the knowledge, understanding, prevention and management of this drug effect. In this work, we report the French experience through pharmacovigilance data.Materials and methods: This is a retrospective stud...

Introduction: The Marine–Lenhart syndrome is a rare cause of hyperthyroidism that is associated with the simultaneous or sequential presence of characteristics related to Graves’ disease and toxic nodular or multinodular goiter. It’s validity as a disease is controversial and some authors believe that these are cases of hyperthyroidism where both etiologies coexist. The presence of hyperfunctioning nodules in Graves’ disease patients ranges between 0.8 and ...

Background: The combination of a toxic adenoma and Graves’ disease compose the Marine-Lenhart syndrome. This condition is estimated to occur in 0.8-2.7% of Graves’ disease patients and only few cases are reported in the literature.Patient findings: A 29-year-old female patient was referred to our outpatient clinic due to subclinical hyperthyroidism and a newly discovered thyroid nodule on the right thyroid lobe. She had no thyreotoxic symptoms ...

A 19-year-old male referred from the Ophthalmology clinic on account of staring gaze of 1 year, and an anterior neck swelling which was noticed 3 months before presentation. Anterior neck progressively increased in size. It was not painful. No history of dysphagia, voice changes or yellowness of the eyes. There was positive history of heat intolerance, weight loss despite increased appetite, irritability, restlessness, palpitations and hyperdefeacation. No history of exposure ...

We report an interference in an immunoassay for aldosterone, which potentially could have led to a wrongful diagnosis and unnecessary surgery. The interference was serendipitously recognized due to a preanalytical error. A 59-year-old female patient with hypertension was referred to the department of endocrinology after an adrenal incidentaloma was detected. Because of her hypertensive history, screening for primary hyperaldosteronism was performed. An elevated aldosterone and...

Introduction: The bone-sparing effect of oestrogen is mediated via oestrogen receptor alpha (ERα), which stimulates transcriptional action through its two activation functions (AF1 and AF2). In addition to these nuclear effects, a fraction of this receptor is targeted to the plasma membrane and triggers membrane initiated steroid signaling (MISS). Whereas, ERα AF1 plays a crucial role in trabecular bone, but not cortical bone, ERα AF2 is necessary for the oestro...