Endocrine Abstracts

Objectives: To describe modifiable sociodemographic and clinical risk factors predictive of severe hypoglycemia with need for urgent health care in adults with type 1 diabetes (T1DM).Methods: Multicenter, observational and retrospective study with case-control design.Cases: T1DM adults with severe hypoglycemia, defined as glycemia <70 mg/dl requiring urgent out-of-hospital health care for its resolution. Data source, geographic...

There is a specific unit specialised in treating differentiated thyroid cancer (DTC) at the Endocrinology Department from a hospital the southwest of Spain that attends patients from two different provinces. Owing to environmental pollution, one of them has higher incidence of cancer.To evaluate the changes in the clinical presentation of DTC over time and analyse possible differences between patients from the two provinces, we designed a descriptive ret...

Craniopharyngiomas (CP) are low-prevalent tumors characterized for their local invasiveness and poor clinical outcomes, often requiring aggressive therapeutic measures. Ki67 is a marker of proliferation with good correlation with tumor recurrence in many solid tumors but this relationship is unclear in CP. Our aim is to determine whether Ki67 could be a marker for recurrence in CP.Material and methods: Descriptive retrospective observational study. All p...

Background: Prostate cancer (PCa) is the fifth leading cause of cancer-related death worldwide. The main pharmacological strategy for this pathology is the blockade of the androgen receptor signalling pathway, commonly known as androgen-deprivation therapy. However, some of the patients does no longer respond to this hormonal therapy. Therefore, finding novel therapeutic strategies to tackle PCa, especially its most advanced phenotype [i.e., castration-resistant prostate cance...

Objective: The aim of this study was to examine the impact of a web-based telemedicine system for monitoring glucose control in pregnant women with diabetes on health care visits, metabolic control and pregnancy outcomes.Subjects and methods: A prospective, single-centre, and interventional study with two parallel groups was performed in Puerto Real University Hospital (Spain). Women were assigned to two different glucose monitoring groups: control group...

Background: Somatostatin (SST)/Cortistatin (CORT) system is a complex hormonal axis involved in the progression of several tumor types. However, its role has not been explored in prostate cancer (PCa), one of the most common type among men.Objectives: We aimed to investigate the presence and the pathophysiological role of SST/CORT in PCa.Methods: We analysed functional parameters in response to SST and CORT and to CORT-silencing in...

Objectives: To know the frequency of hypertension in a group of males with type two diabetes without the antecedent of hypertension, by means of ambulatory blood pressure monitoring (ABPM). To assess the possible differences between the subjects with and without hypertension in age, time of duration of diabetes, obesity and the features of metabolic syndrome.Methods: We included consecutively 55 males with type two diabetes without the antecedent of hype...

Obesity (OB) and type-2 diabetes (T2D) are chronic endocrine-metabolic diseases, associated to insulin-resistance (IR), that represent capital health problems. Fortunately, both pathologies are, at least, partially reversible by dietary interventions, but the potential metabolic, molecular, cellular factors and mechanisms that might be involved in the total/partial reversion of OB/IR/T2D by dietary interventions are poorly known. Thus, in this work, we aimed evaluate the impac...

Emerging evidence indicates that the cellular machinery controlling the splicing process (spliceosome) is altered in several tumour types, leading to oncogenic splicing events associated with tumour progression and aggressiveness. However, whether this molecular phenomenon also occurs in thyroid cancer has not been yet explored. Therefore, our main aim was to explore the potential dysregulation of the expression of relevant spliceosome components and splicing factors in clinic...

Prostate cancer (PCa) is one of the most common endocrine-related cancers (ERCs) among men worldwide. The aggressiveness of this tumor pathology is highly influenced by different endocrine-related factors, highlighting the crucial role of androgens. Therefore, the main therapeutic approach for PCa patients is based on the pharmacological blockade of androgen-signaling. However, some patients become unresponsive and develop a highly lethal castration-resistant disease, pointing...