Endocrine Abstracts

The aim of the study was to defined the level of rehabilitation after the stroke depending on the type of hyperglycemia.Materials and methods: The retrospective analysis of 122 (54 female and 68 men) cases of ischemic stroke (IS) has been done. The diagnosis of IS was confirmed by computer tomography. According to the level of hyperglycemia at the debut of IS the patients were divided into three groups. Group 1 (60 patients) – with normoglycemia, gr...

Secondary hyperparathyroidism (SHPT) as well as vitamin D deficiency are highly prevalent in patients with chronic kidney disease (CKD). Traditional therapy of SHPT includes administration of calcitriol, mainly in dialysis patients. Data about effects of native vitamin D repletion in such patients are still inconsistent. The aim was to assess effects of vitamin D repletion in CKD patients with SHPT and vitamin D deficiency. 88 patients, mean age 50.8±14.6 years with CKD 3...

Secondary (SHPT) is frequent in patients with chronic kidney disease and can predispose patients to low bone mineral density (BMD). Necessity of BMD assessment in such patients is controversial.The aim was to analyze BMD and PTH secretion in patients with different stages of chronic kidney disease. We examined 311 patients, 161 f, 150 m; age 49.2±14.4 yrs; 190 patients are on continuous dialysis due to end-stage chronic kidney disease (mean dialysis...

The aim was to estimate Vitamin D3 (25OHD) level and it’s relation to secondary hyperparathyroidism (SHPT) development in patients with different stages of chronic kidney disease (CKD).We examined 114 patients, 71 f, 43 m; age 44.6±14.3 years. CKD stage was defined by estimated glomerular filtration rate (eGFR) calculated by MDRD formula. 48 patients have CKD stage 1–2, 26 pts – CKD3, 27 pts – CKD4, 13 pts – CKD5 (not on dia...

The aim was to analyse dynamics of PTH secretion in dialysis patients during different period of observation and to determine factors of secondary hyperparathyroidism progression. We examined 92 patients, 52f, 40m; age 47.2±11.4 years; dialysis duration 4.9±3.9 years; mean observational period 8.9±4.3 months (6–24). Serum PTH, 25(OH)D3, osteocalcin (OC), C-terminal telopeptide of type I collagen (β-CTx), alkaline phosphotase (ALP), calcium (Ca), and ph...

The international classification of functioning, disability and health, known more commonly as ICF, is a classification of health and health-related domains. These domains are classified from body, individual and societal perspectives by means of two lists: a list of body functions and structure, and a list of domains of activity and participation. Since an individual’s functioning and disability occurs in a context, the ICF also includes a list of environmental factors.<...

Objective: To evaluate the hydrolytical activity of autoantibodies (Ab) to double-stranded DNA using atomic force microscopy in patients with autoimmune thyroiditis.Methods: Ab to double-stranded DNA (dsDNA) IgG class were isolated from the serum of patients with autoimmune thyroiditis by DNA-affinity chromatography. Hydrolytical activity of Ab to dsDNA was confirmed by Polyacrylamide Gel Electrophoresi (PAGE). The images of Ab to dsDNA and results of ds...

Introduction: The management of clinically non-functioning pituitary adenomas (NFPA) remains a debated issue. Surgery, which is indisputably indicated in invasive NFPA, is rarely curative. Moreover, it is not always feasible due to potential complications or contraindications. Expression of somatostatin receptors (SSTR) form the rationale for the use of somatostatin analogues (SSA) in NFPA.Aim: To compare the risk of NFPA progression in patients treated ...

A few years ago a novel multiple endocrine neoplasia syndrome, named MEN type 4 (MEN4), was discovered thanks to studies conducted on a MEN syndrome in the rat (named MENX). Rat and human syndromes are both caused by germline mutations in the Cdkn1b/CDKN1B gene encoding p27Kip1, a putative tumor suppressor which binds to and inhibits cyclin/cyclin dependent kinase complexes, thereby inhibiting cell cycle progression. MEN4 patients carry heterozygous mutations...

MENX is a recently identified multiple endocrine neoplasia (MEN) syndrome in the rat. Affected animals develop multiple neuroendocrine tumors (NETs) with high penetrance and at young age, specifically: bilateral pheochromocytoma (100%), multifocal pituitary adenoma (100%), multifocal thyroid C-cell hyperplasia, parathyroid hyperplasia, extra-adrenal pheochromocytoma (paragangliomas) and pancreatic islet cell hyperplasia. MENX is caused by a germline frameshift mutation of the ...