Endocrine Abstracts

Background: Well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are commonly characterized by overexpression of somatostatin receptor subtype 2 (SSTR2), which can be targeted by radiopharmaceutical therapy (RPT) via radiolabeled somatostatin analogues (SSAs). RYZ101 (Ac-225 DOTATATE) is a first-in-class, highly potent alpha-emitting RPT being developed for the treatment of SSTR2+ solid tumors. Alpha-particles (such as emitted by Actinium-225) have a sho...

Samuel Refetoff, University of Chicago, IL, USA. AbstractSamuel Refetoff is known for his discovery (1967) of resistance to thyroid hormone (Refetoff Syndrome) and elucidation of its genetic and molecular basis (1989/92).Devoted to the study of inherited thyroid disorders, his laboratory was first to identify mutations in: serum TH transport proteins [TBG (1989) and albumin (1994)]; the TSH rece...

Prostate cancer (PC) becomes resistant to chronic castration via an adaptive increase in androgen receptor (AR) axis activity. AR overexpression, however, is a liability that can be exploited therapeutically through rapid cycling between high supraphysiologic and low castrate levels of serum testosterone (T), (Bipolar Androgen Therapy (BAT)). In a pilot study, 14 men with CRPC treated with BAT showed a 50% PSA and objective response. A larger study was initiated in which asymp...

The focus of this talk is on how disruptions in the ability of organisms to appropriately store and release lipid can impact on whole organism metabolic health. The talk focuses predominantly on murine phenotyping and discusses how observations from mice can be related to human data.Both healthy mice and humans preferentially use carbohydrate in the fed state and switch to utilising a greater degree of lipid in fasted state. The ability to perform the sw...

At least six major steps are required for secreted thyroid hormone to exert its action on target tissues: thyroid hormone transport into cells, intracellular activation of the prohormone thyroxine, transfer of the hormone from the cytoplasm to the nucleus, intact thyroid hormone receptors and intact nuclear and cytosolic machinery required for the mediation of thyroid hormone action. Mutations interfering with three of these steps have been so far identified and are the subjec...

Glucose uptake is mediated by a family of glucose transport proteins, which are known to be expressed in specific insulin-sensitive tissues. Magnesium (Mg) is essential for autophosrylation of insulin receptor (INSR) and translocation of glucose transporter 4 (GLUT4) to the plasma membrane to facilitate glucose homeostasis. The specific effect of magnesium on INSR and GLUT4 expression in a diabetic state is however lacking. We conducted this s...

Glucose uptake is mediated by a family of glucose transport proteins, which are known to be expressed in specific insulin-sensitive tissues. Magnesium (Mg) is essential for autophosrylation of insulin receptor (INSR) and translocation of glucose transporter 4 (GLUT4) to the plasma membrane to facilitate glucose homeostasis. The specific effect of magnesium on INSR and GLUT4 expression in a diabetic state is however lacking. We conducted this s...

Introduction: Our current local management guidelines for Graves’ Disease (GD) in children and young people (CYP) do not include routine screening for coeliac disease (CD). However, ad hoc testing of patients in this cohort pointed to a high incidence of positive tissue transglutaminase (TTG) results.Aims/Objectives: 1. To determine the incidence of CD in patients in our service diagnosed with GD. 2. To establish if...

Background: This study was aimed at examining the association between the fertility parameters and periodontal status of men, with reference to the bacterial culture analysis of the semen and mouth swab, seminal fluid parameters and blood serum parameters.Method: 43 men consisting 30 infertile men as test subject, and 13 fertile men as control aged 30–50 years were selected for this research. Semen samples were analysed to determine microbial presen...

Thyrotoxicosis is a relatively common condition affecting 1–2% of women and 0.1–0.2% of men. Common symptoms are usually straightforward and easily identified. Rarer presenting features such as confusion and headache have been published in the literature as case reports. We hereby report two cases of Graves Thyrotoxicosis presenting unusually and therefore misleading the initial diagnostic pathway. The first case is a 45-year-old female with a 4-day history of headac...