Endocrine Abstracts

BackgroundSuspicion of Cushing´s syndrome (CS) is usually suggested by non-specific clinical data. Chronic hypercortisolism associates changes in white blood cell count (WBC), essentially a higher count with relative lymphopenia. Our purpose is to investigate the prevalence of these findings among a local series of patients with Cushing’s syndrome before and after the hypercortisolism revertion to assess the diagnostic value of these parameters...

Introduction: HypoPTH is an uncommon disorder, mostly due to anterior neck surgery. The prevalence of HypoPTH has been studied in surgical series and registries, (USA, Denmark and Hungary) where only a minority of patients has HypoPTH due to non-surgical causes. In Spain data on PO HypoPTH in endocrinologist clinical practice has been published recently. The aim of this study was to establish the prevalence of chronic PO HypoPTH in Bilbao area, with a population 2019: 346,843....

Rothmund-Thomson syndrome (RTS) usually presents with physical stigmata (poikiloderma, ectodermal dysplasia, juvenile cataracts…) and it´s associated with malignancies in patients with homozygous or compound heterozygous mutations in the RECQL4 helicase gene (RTS-II). Neoplasms include osteosarcoma in childhood and skin cancer later in life, with occasional malignancies affecting other tissues (leukemia, lymphoma and gastrointestinal adenocarcinomas). To ou...

Early diagnosis of CS could reduce the morbidity and mortality associated with endogenous hypercortisolism. Many clinical methods have been proposed to establish suspicion of CS, but they show a poor positive predictive value (PPV) and are sometimes difficult to assess. Assuming the well-known influence of hypercortisolism on white blood cell (WBC) count, we evaluated its potential usefulness as a screening test to trigger this suspicion. We analysed WBC count around the diagn...

Introduction: Papillary thyroid cancer (PTC) is usually tied to an excellent prognosis, with a 10-year disease specific survival rate of 98%. Nevertheless, some clinicopathological features are associated with a worse outcome. Therefore, a precise risk assessment is crucial for the clinicians deciding the most appropriate treatment for each tumour. Multifocal tumours (MFPTC) appear to have be a worse prognosis than unifocal tumours (UFPTC) in some series, but this aspect is di...

Introduction: American Thyroid Association (ATA) guidelines suggest considering hemithyroidectomy in patients with unifocal well-differentiated thyroid tumours,smaller than 4 cm, withoutpreoperative evidence of extrathyroidal extension (ETE) nor lymph node metastases. Although multifocal microcarcinomas are considered to increase the risk of structural disease recurrence from 1%–2% to 4%–6% compared to unifocal microcarcinomas, the ATA guidelines do not sugges...

Procalcitonin (PCT) is a sepsis diagnostic marker and mortality predictor, although its elevation can be related to other diseases such as medullary thyroid carcinoma (MTC). A 72-year-old woman was transferred to the intensive care unit of our institution from another center. One week before, she had been admitted with a clinical picture of progressive malaise, fever, and dyspnea. Weeks before her admission, she had consulted for dyspnea, anorexia, asthenia, and weight loss. I...

Despite being the most successful definitive treatment for GD and offering the best response in terms of quality of life, thyroidectomy is rarely performed worldwide. Few studies evaluate its complication rate and potential prognostic factors for complications. We report our last ten years’ experience. Incidence of temporary and permanent hypoparathyroidism, temporary and permanent recurrent laryngeal nerve (RLN) injury and incidental malignancy were recorded, looking for...

Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly called non-alcoholic fatty liver disease, NAFLD) is a leading cause of chronic liver disease, affecting 25% adult population worlwide. Its most advanced form is the metabolic dysfunction-associated steatohepatitis, or MASH which may progress to cirrhosis. It has no approved pharmacotherapy yet, and weight reduction is an important therapeutic option. Few studies have evaluated the effect of...

Neuroprotection defines a set of homeostatic, self-repair mechanisms that probably evolved for the specially demanding conditions imposed by brain function. Among these, intercellular messengers such as the insulin-like growth factors (IGFs), that appeared very early during phylogeny, apparently play a prominent role despite their peripheral origin. In contrast to the heterogeneity seen in primitive organisms where at least 30 different IGF-like peptides are described, in mamm...