Endocrine Abstracts

Introduction: Many people with type 1 diabetes continue to experience suboptimal glycaemic control. We now also know that often HbA1c levels are an inaccurate reflection of glycaemic patterns and variability. We describe here how the systematic use of the FreeStyle Libre flash monitor helped improve the glycaemic control of many people with type 1 diabetes.Methods: We report the outcomes of 92 consecutive adults (18 years of age or more) with type 1 diab...

Background: The University Teaching Hospital Trust has a regional neuroendocrine tumour (NET) service that requires a database exclusively for NET patient information. UK and Ireland NET Society (UKINETS) guidelines for gastroenteropancreatic (GEP) NETs recommend plasma Chromogranin-A (Cg-A) and 24 h urinary 5-hydroxyindoacetic acid (24 h Ur 5-HIAA) as baseline investigations. This audit investigated both guideline adherence and the value of these tests in making the diagnosis...

Introduction: Osteoporosis poses a significant public health issue, causing significant morbidity and mortality. It leads to an increased fracture risk through a reduction in the bone mineral density (BMD), disruption of bone microarchitecture, and alteration of the amount and variety of non-collagenous proteins in bone. Treatment aims are to prevent fractures and maintain the quality of life of the aging adult. The advent of the WHO assessment tool ‘Fractur...

The Guideline ‘Menopause: Diagnosis and Management’ was published by the National Institute of Health and Care Excellence (NICE) in the UK in November 2015, the aim being to improve the knowledge level of both health care professionals and their patients regarding the menopause and to standardise care across the UK. Recommendations were developed following the systematic review of the current evidence-base. Each review question posed (17 in all) was subject to system...

The Guideline ‘Menopause: Diagnosis and Management’ was published by the National Institute of Health and Care Excellence (NICE) in the UK in November 2015, the aim being to improve the knowledge level of both health care professionals and their patients regarding the menopause and to standardise care across the UK. Recommendations were developed following the systematic review of the current evidence-base. Each review question posed (17 in all) was subject to system...

Background: Wolfram syndrome is an autosomal recessive neurodegenerative disorder characterised by Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Deafness (also referred to as DIDMOAD). An estimated prevalence is 1 in 770,000 and an estimated carrier frequency is 1 in 354. Herein, we describe the course of wolfram syndrome in two female siblings.Case presentations: The first patient is a 30-year ...

Primary aldosteronism (PA) has a prevalence of 5–15% in the general population with hypertension and patients with PA display an increased frequency of target organ damage and cardiovascular damage than patients with hypertension with matched cardiovascular risk profiles. The unilateral and bilateral forms of PA are treated differently usually surgically (unilateral PA) or by antagonism of the receptor for aldosterone (bilateral PA). Medically-treated patients with PA hav...

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Subjects with Prader-Willi syndrome (PWS) need a comprehensive care of a multi-disciplinary team from childhood to adulthood. It is not only growth, body composition and sexual maturation that are compromised in PWS. The complications due to overweight like Type-2 Diabetes and cardio-vascular disorders need to be prevented already during childhood. The psychiatric well-being of individuals with PWS is important to focus on and also to discover co-morbidities like autism to be ...

Rescuing neurons from death and promoting axon regeneration through the delivery of individual neurotrophic factors (NTF) to the CNS has proved disappointing. We evaluated in vitro the potency of FGF2, NT-3, and BDNF given singly, or in combination, to trophically support retinal ganglion cells (RGC) in the presence of inhibitory CNS myelin, and demonstrated increased survival and neurite outgrowth greater than the sum of the effects of each NTF given alone. We observed...