Endocrine Abstracts

Endocrine nursing practice has been changing, with the advent of more autonomous roles, involving nurse led clinics and independent prescribing, with more complex clinical case management. However, recent research highlights the emphasis on optimum patient care, but scope of practice is not always clear, leading to unequal balance in skills and capabilities, qualifications, and Agenda for Change (AfC) bandings. This study explored the remit, job components, and capabilities of...

Obesity and diabetes mellitus type 2 are proinflammatory states associated with increased disease severity in rheumatoid arthritis (RA). Weight loss is associated with improved disease activity in rheumatoid arthritis (RA). Furthermore science experiments demonstrated weight-independent anti-inflammatory and immunomodulatory effects of GLP-1 receptor agonists. Moreover, in vitro studies found anti-inflammatory effects of GLP-1 receptor agonists in fibroblast-like syno...

Background: Most obesity management programs use short term weight loss as the main monitoring parameter. Change in weight can be a misleading measure as it can be impacted by various factors and most participants regain weight after exiting such programs1. The aim of this project is to assess the efficacy of focusing on self-selected, non-weight loss goals in encouraging long term obesity management.Methods: ...

Superoxid dysmutase (SOD) is a key antioxidant enzyme engaged in detoxication of superoxide radicals. Ala/Val substitution in Mn SOD leads to a change in the effectiveness of the action of the enzyme. This polymorphism we analyzed among several groups patients with diabetes and we compared with control group of healthy volunteers. It is proved an association connection of tracked marker in some of the groups of patients with diabetes compared to the rest population sample. Suc...

Journal of Molecular Endocrinology, 2022, 68(2), 99-110 (DOI: https://doi.org/10.1530/JME-21-0175): ...

Insulin resistance and androgen excess are the cardinal features of polycystic ovary syndrome (PCOS). The severity of hyperandrogenism and metabolic dysfunction in PCOS are closely correlated but the underlying mechanisms are poorly understood. Aldoketoreductase type 1C3 (AKR1C3) is an important source of adipose androgen generation (converting androstenedione to testosterone) and we have postulated that it may have a critical role linking androgen metabolism and meta...

In order to determine the influence of PCOS and obesity on vascular parameters, we studied 25 patients with PCOS (10 with normal body mass index – BMI – and 15 obese) without classic cardiovascular risk factors (IGT or DM, arterial hypertension, dyslipidemia) and 23 control women (12 with normal BMI and 11 obese), pairwise matched for BMI, through a non-invasive method using high resolution ultrasound imaging. Global age range was 26.0±4.7 years. The mean values...

A genome wide meta-analysis by the CORtisol NETwork (CORNET) consortium1 has identified genetic variants spanning the SERPINA6/SERPINA1 locus on chromosome 14 associated with changes in morning plasma cortisol and predictive of cardiovascular disease (Crawford et al, Unpublished). SERPINA6 encodes Corticosteroid Binding Globin (CBG) which binds most cortisol in blood and influences delivery of cortisol to target tissues. We hypothesised th...

Insulin resistance and androgen excess are the cardinal features of polycystic ovary syndrome (PCOS). The severity of hyperandrogenism and metabolic dysfunction in PCOS are closely correlated, but underlying mechanisms remain poorly understood. Aldoketoreductase type 1C3 (AKR1C3) is an important source of adipose androgen generation, activating androstenedione to testosterone (T). We postulated that AKR1C3 plays a critical role linking androgen metabolism and...

Introduction: Congenital hypothyroidism (CHT) has a reported incidence of 1:3500 in Caucasian populations. Early detection by newborn screening and appropriate L-thyroxine treatment leads to normal or near-normal neurocognitive outcome.The National Newborn screening programme (NNP) was established in Children’s University Hospital, Temple St. in 1979. This study aimed to ascertain the incidence of congenital hypothyroidism in the Republic of Ireland...