Endocrine Abstracts

A 48 years old male presented with an acute episode of dizziness, weakness, diaphoresis, palpitations, and shakiness. Hypoglycaemia was confirmed with a CBG of 1.6 mmol/L. His symptoms resolved on treatment with Hypostop gel and 10% dextrose. He had an otherwise unremarkable physical examination. In view of his history of consumption of a bottle of vodka daily a diagnosis of alcohol induced hypoglycaemia was made on discharge. A year later he was found being agitated and aggre...

Introduction: We undertook a service development audit within our trust to review the Medical team’s knowledge on DKA and the management involved in treating these patients. The aim was to identify where there was a lack of knowledge in this area so we could provide teaching sessions on DKA and aim at the specific areas highlighted from the audit. We went on to deliver education sessions on DKA management and pinpointed the areas lacking from the pre audit. The education ...

Background: Hyperandrogenism in congenital adrenal hyperplasia (CAH) is associated with virilisation in female patients and subfertility in both male and female patients. However, little is known regarding the association of hyperandrogenaemia with polycythaemia. We evaluate the association between the adrenal hormone profile and haematocrit (HCT)/haemoglobin (Hb) in a cohort of patients with classical CAH.Methods: Single centre retrospective analysis of...

Twelve-month-old GK rats that showed glucose intolerance were compared with age matched Wistar rats. The concentrations of noradrenaline (NA), adrenaline (ADR) dopamine (DOP), Neuropeptide Y (NPY), and calcitonin gene-related peptide (CGRP) were measured in tissue samples. The objective was to assess whether glucose intolerance was associated with changes in the noradrenergic and peptidergic nerves innervating the tail artery (TA), seminal vesicle (SV) and corpus cavernosum (C...

Osteoclasts are long lived highly specialised bone resorbing cells which form through the fusion of mononuclear pre-cursor cells and are believed to follow a linear fate and undergo apoptosis at the end of their life cycle. A number of anti-resorptive therapeutics target these cells, either preventing their resorptive function, Bisphosphonates, or inhibiting their formation, Denosumab (Anti-RANKL-Dmab). These agents have achieved success i...

Aims: Exercise increases beta cell health in people at risk of, and with established type 2 diabetes (T2D). These benefits of exercise have not been characterised in T1D. Over 10% of beta cells are still present at the time of diagnosis with T1D, and exercise has the potential to preserve them. We aimed to explore the mechanisms through which exercise could improve beta cell health in T1D by investigating the effects of exercise serum on apoptosis and proliferation of the MIN6...

Episodes of in-hospital hypoglycaemia are uncommon but serious events, which cost the NHS financially and cost the patient in terms of poor clinical outcomes, and rarely, mortality. The National Patient Safety Agency reported that in 2007, one in four adult diabetics experienced an episode of hypoglycaemia whilst in hospital. Moreover, one in 30 required i.v. glucose or i.m. glucagon therapy, and between 2003 and 2009 there were four deaths involving insulin overdose2</su...

In Northern Ireland the annual marching season starts around April/May and can last until the end of September. This is a time when those children and young people with Type 1 Diabetes Mellitus who are involved in parades, need advice from the diabetes team regarding the variations in their activity levels. This can be a very delicate subject within the cultural setting, revealing their allegiance for one side of the community or the other and can be very sensitive. As a resul...

MLE4901 (previously AZD4901) is a potent and selective neurokinin 3 receptor (NK3R) antagonist being developed for the treatment of polycystic ovary syndrome (PCOS). Clinical studies indicate the compound negatively regulates the hypothalamus-pituitary-gonadotropin (HPG) axis to reduce pituitary luteinizing hormone and gonadal sex steroids. To understand the longer-term in vivo effects of MLE4901, a 13-week safety study was carried out. Groups of 3 male and female dog...

Background: Autoimmune Addison’s disease (AAD) is a rare endocrinopathy arising from a complex interplay between multiple genetic susceptibility polymorphisms and environmental factors. Several variants in immune pathways have been identified through hypothesis-driven candidate gene analysis, though these associations can prove difficult to replicate. The first genome wide association study (GWAS) with patients from Scandinavian Addison’s registries identified associ...