Endocrine Abstracts

Background: Primary bilateral bilateral macronodular adrenal hyperplasia is a cause of Cushing’s syndrome. It is characterised by a large enlargement of the adrenal glands at the expense of multiple non-pigmented nodules. There is inefficient steroidogenesis.Summary of the case: A 58-year-old woman with a history of extreme obesity, type 2 diabetes mellitus, hypertension and dyslipidaemia was admitted to our hospital for cellulitis and anaemia secon...

Cardiovascular disease (CVD) is more prevalent in patients with chronic kidney disease (CKD) and Diabetes mellitus (DM) than in the general population. Microparticles (MPs) released during cell activation and/or apoptosis could be biomarkers of CVD. These MPs, which show vascular damage, are named according to the injured cell, as endothelial (EMPs) or platelet (PMPs).AimAssess the MPs plasma concentration in diabetic pati...

Introduction: Ketosis-prone diabetes or Flatbush diabetes has been recognized as a clinical entity since 1984. Is characterized by diabetic ketosis or ketoacidosis occurring soon after the onset of hyperglycemic syntoms (usually poyiuria, polydipsia and weight loss are present for less than 4 weeks). Unlike the insulin dependence seen in type 1 diabetes, after a few weeks (usually 2 to 12 weeks), insulin requeriments decrease, and approximately 70% of patients achieve remissio...

Introduction: NutriScore is a tool designed with the aim of simplifying the information of the nutritional composition obtained from the labelling. It classifies foods into five colors ranging from green (healthier) to red (less healthy). These colors are associated with five letters (A/B/C/D/E).Objective: To examine the nutritional value of foods sold in vending machines of the public hospitals in Community of Madrid (Spain), by calculating the nutrisco...

Abstract unavaialble....

Obesity is defined as an excess of adipose tissue of sufficient magnitude to produce adverse health consequences, and is associated with increased morbi–mortality. BMI is the most frequently used diagnostic tool in the current classification system of obesity. It has the advantage that a subject’s height and weight are easy and inexpensive to measure. Overweight is defined as a BMI between 25.0 and 29.9 kg/m2 and obesity as a BMI ≥30.0 kg/m2</su...

Xavier Bertagna, Cochin Hospital, Paris, France. AbstractXavier Bertagna is Professor of Endocrinology, Chief of the Department of Endocrinology of Cochin hospital, Faculté de Médecine René Descartes, Université Paris, Paris, France.He trained at the Clinical Research Center (Dr. M. Chrétien), Montreal, Canada and at the Endocrine Division, Vanderbilt Medical School (Dr....

Background: Alpelisib is an α-selective PI3K inhibitor indicated for the treatment of postmenopausal women and men with hormone receptor-positive (HR+), human epidermal growth receptor 2-negative (HER2–), PIK3CA-mutated locally advanced or metastatic breast cancer following disease progression or after endocrine therapy. Hyperglycemia is the most common adverse event (up to 60%) associated with its use. It occurs more frequently and lasts longer in patients with pred...

Objectives and methods: The mechanism that explains the different weight response to various treatments in obese type 2 diabetes (DM2) patients, compared to those without diabetes, is still unknown. In order to establish the weight response to Roux-en-Y Gastric Bypass (RYGB), 268 patients with morbid obesity (IMC 45.4±0.4 kg/m2) were classified by OGTT as having normal glucose tolerance (Grupo A. n=107), prediabetes (Grupo B. n=96) an...

Background: There is a clear relationship between obesity and carbohydrate metabolism alterations (CMA), such as impaired glucose tolerance (IGT) and T2D. OGTT is used for the diagnosis of those alterations, but is not performed in case of normal fasting glucose values (NFG). Moreover, BMI underestimates the diagnosis of obesity and body composition alteration can be crucial to the development of abnormal carbohydrate metabolism. This study aimed to examine the discriminating ...