Endocrine Abstracts

Introduction: Bardet-Biedl syndrome (BBS) is a rare autosomal recessive genetic disorder involving hypogonadism manifested by cryptorchidism, micropenis and/or delayed pubertyObservation: We report the case of a 13 year old child, who was consulted for obesity and whose physical examination showed major signs of SBB: global obesity, polydactyly, learning difficulties and visual disorders. Genital examination revealed a 1 cm genital tubercle with a single...

Background and aims: It has been demonstrated that the thyroid autoimmunity, during pregnancy, adversely affects the course of the pregnancy. The anomalies may be prior to the conception, hence the interest of studying the women during the genital activity period. Our objective was to determine the prevalence of the thyroiditis in childbearing age women.Materials and methods: Prospective study, on 270 childbearing age women. Study protocol: clinical exam...

Background and aims: The hypothyroidism may be prior to the conception, hence the interest of studying women during the genital activity period. Our objective was to determine the prevalence and the etiologies of the hypothyroidism in childbearing age women.Materials and methods: Prospective study, on 270 childbearing age women. Study protocol: clinical examination, urinary iodine, thyroid stimulating hormone (TSH), free thyroxine (FT4) and thyroid antib...

Introduction: Iodine deficiency has serious consequences for both the mother and the offspring, it is a real public health problem. Our aim was to study the iodine status impact on thyroid parameters during the first trimester of pregnancy in women free of any current or previous thyroid disease.Patients and methods: Prospective study, on 145 pregnant women (mean age of 29.4±0.5 years) at 10.4±0.2 weeks of gestation. Women with disrupted thyroi...

Introduction: Hypothyroidism is known for its adverse effects for both the pregnant woman and her offspring. Our aim is to highlight the benefits of screening for hypothyroidism in all pregnant women with and without risk factors.Patients and methods: Prospective study, on 270 pregnant women. Women with disrupted thyroid balance, who smoke (active smoking confessed) and those followed for thyroid disease or taking medications that interfere with the thyr...

Autoimmune thyroiditis (AIT) is a group of inflammatory thyroid disorders with either hyperthyroid, euthyroid or hypothyroid state. The aim of this study is to detect the subclinical thyroiditis among the Egyptians type 1 diabetic patients and to study the relation of the thyroid antibodies to different metabolic control indices of diabetes. The study group consisted of 50 type 1 diabetic patients aged from 8 to 18 years. They were selected from the out-patient daily clinics o...

Ramadan is a holy month in the Muslim religion, it involves a period of daily fasting from sunrise to sunset, which means an average of fifteen hours of fasting during the day (twelve to eighteen hours depending on seasons and regions). In diabetics, this involves metabolic disorders related to fasting, food mode (quantitative and qualitative change in dietary intake). The objective of our study is to define the profile of diabetic patients seen in the emergency department and...

Introduction: 3-Iodothyronamine (T1AM) is a novel endogenous relative of thyroid hormone able to interact with specific G protein-coupled receptors, known as trace amine-associated receptors (TAAR). Metabolic, endocrine and cardiac effects of exogenous T1AM have been reported.Methods: We synthesized radiolabelled T1AM, [125I]-T1AM, and explored its distribution in different mouse organs after injection in the tail vein. The specificity of [<su...

Introduction: Excess weight has become a major public health problem. Type 2 diabetes and obesity are known risk factors for kidney disease. The aim of this study is to determine the effect of obesity on glomerular filtration rate (GFR) and microalbiminuria in patients with diabetes.Methods: This is a descriptive cross-sectional study conducted over three years in obese and type 2 diabetic patients hospitalized in the Endocrinology and Diabetology Depart...

Introduction: Acromegaly is an underdiagnosed condition that is responsible for multiple complications. The purpose of this work is to examine the prevalence of these complications at time of diagnosis.Patients and methods: This retrospective study included 10 patients diagnosed with acromegaly followed in the endocrinology – diabetology department of Mohamed VI university hospital.Results: Mean age at diagnosis was 49 years w...