Endocrine Abstracts

Introduction: Hypopituitarism is the most frequent side effect of radiation or gamma knife radiosurgery (GKRS) for sellar diseases. There is a paucity of literature on the impact of GKRS on the hormonal profile of non-sellar diseases, even though the impact of radiation on pituitary hormones has been widely explored in sellar as well as non-sellar pathologies. In patients receiving treatment for non-sellar diseases, we assessed the effect of GKRS on hormonal p...

Background: Lithium remains a first-line treatment for bipolar affective disorder and acute maniac states.Lithium therapy is associated with a variety of side effects including thyroid dysfunction and hypercalcaemia. Hypercalcaemia and more rarely biochemical picture resembling primary hyperparathyroidism or familial hypocalciuric hypercalcaemia may develop. Recognition of this side effect is of vital importance as an increasing number of patients with b...

Introduction: It has been seen that Zoledronic acid (ZA) infusion induces an acute inflammatory response associated with rise in inflammatory markers and changes in thyroid function tests resembling non thyroidal illness syndrome. It is also postulated that amino group of ZA has a role in causation of these thyroid function abnormality. (1)Material and methods: An observational study at tertiary care hospital of India where thyroid functions tests were s...

A young female presented concerned that she may have Addison’s disease. She had noted increasing pigmentation and reported her sister had died from undiagnosed Addison’s disease. She was hypotensive, with no postural drop in her blood pressure. She was hyponatraemic and hyperkalaemic. An initial 250 μg Synacthen test performed in the afternoon gave a baseline cortisol of 258 nmol/L and a 30 minute cortisol of 291 nmol/L. In view of this, the Synacthen test was r...

ObjectThe aim of the study was to evaluate the peripartum changes in the level of TSH and thyroid function, due to dietary iron deficiency anaemia. Iron deficiency anaemia is widely prevalent in developing countries like India. It is the most pervasive of all nutritional deficiencies, particularly affecting women especially pregnant women. It is very important to note the changes in the thyroid activity by severe anaemia during peripartum period.<p c...

The present study was aimed to investigate the 24 hours chronomics of BP/HR in terms of Double amplitude, Acrophase and Hyperbaric index and its relation with circadian rhythm of 6-sulfatoxy melatonin in night shift nurses and actual day workers. 56 night shift nurses, aged 20–40 years, performing day and night shift duties were recruited from the Trauma Center, KGMU, India, and 56 age sex matched actual day workers were also enrolled as controls. BP and HR were recorded ...

Objectives: The present aimed to investigate the circadian pattern of salivary cortisol & sulfatoxy melatonin level in night shift professionals and actual day workers & to find out these changes in the circadian pattern produce by night shift are reversible in due course of time.Methods: 56 Nursing professionals of both gender who perform day and night shifts and 56 actual controls were also recruited in this study. Saliva and urine samples were...

Background & aim: Night shift work is associated with a disruption of circadian rhythms, where a person’s internal body clock is in conflict with the rotating shift schedule. The circadian rhythm of the human body is characterized with an alternating sleep-wake cycle. Shift work has been associated with increased risk of hypertension, cardiovascular diseases and hormonal disturbances. The Present study was aimed to investigate the effects of rotating night shift on 24...

Objectives: The present study investigate the effect of light at night and rotating shift on circadian pattern of salivary cortisol and melatonin sulphate level in night shift workers and to find out whether these changes in the circadian pattern produce by night shift are reversible in due course of time. Sleep loss may be a novel risk factor for various hormones and sleep disturbances leads to metabolic and endocrinal disorders due to interference with diet, circadian metabo...

Background: Atypical antipsychotic agents are useful in treating patients with schizophrenia and other psychoses, but may cause hyperglycaemia. Hyperglycaemia is not dose dependent and is reversible on stopping the treatment.Occurrence of diabetes after atypical antipsychotic drug administration is of major concern as patients may not recognise their symptoms, and health workers may fail to reach an early diagnosis, with major implications for morbidity ...