Endocrine Abstracts

Introduction: Lutetium-177-DOTATATE (Lu177) is approved in patients with well-differentiated (G1 and G2) neuroendocrine tumors (NETs) positive to somatostatin receptors, progressive and unresectable or metastatic. Lu177 has been shown to increase progression-free survival and the quality of life of these patients.Material and Methods: Retrospective descriptive study of a series of 15 cases with NETs treated with Lu177. Demographic data, tumor characteris...

The adolescent/young adult who requires pubertal induction presents unique challenges to the health care team. Nurses serve as a key resource for patients and their families during the process of pubertal induction. Health promotion is the keystone of nursing practice and a developmental model is an appropriate framework to tailor nursing assessment and intervention to the adolescent/young adult’s developmental level. The nurse’s role in health promotion during puber...

Case History: A 46 year old lady presented to A&E with a 4 day history of headache, vomiting, abdominal pain and fever. On further questioning, she admitted to having had experienced occasional episodes of palpitations, hot flushes and headaches over the past few months. She had history of appendectomy when she was young and acoustic neuroma removal few years ago. She wasn’t on any regular medications. On clinical examination, she looked visibly unwell and was hypoxic...

Background and aims: The mechanisms in HIV by which mitochondrial dysfunction occurs, leading to impaired energy homeostasis and metabolic regulation, are unclear; although similarities are noted in T2DM. Therefore, we investigated the effect of HIV status and ARV therapy on several mitochondrial and nuclear encoded genes related to mitochondrial metabolism and energy homeostasis.Materials and methods: Subcutaneous AT biopsies from the ileac crest were o...

Introduction: The main indications for the somatostatin analogues (SST-A) are acromegalies and/or neuroendocrine tumors. They can increase fecal fats, which could lead to the loss of fat soluble vitamins. There are few published studies showing the effects of the long-term use.Methods: Retrospective study of patients with SST-A indicated from our endocrinology department in the last 10 years. We analysed indications and different epidemiological, clinica...

Introduction: Ectopic Cushing Syndrome (ECS) is a rare disease associated with significant comorbidity. Among the causes of Cushing’s syndrome (CS), ACTH-producing extrahypophyseal tumours are rarely reported. The aim of our study is to describe the clinical, diagnostic and therapeutic characteristics of patients with ECS treated in our Endocrinology department over a 15-year period.Methods: A cross-sectional unicentric retrospective study was desi...

Introduction: Neurofibromatosis type 1 (NF1) is an autosomal dominant condition with an incidence of 1 in 2600 to 3000 individuals. Patients with this disorder are characterized by multiple neurofibromas, caf-au-lait macules, axillary freckling, optic gliomas, iris hamartomas, and skeletal abnormalities. Overall risk of developing neoplasms is approximately 2 to 4-fold higher in patients with NF1, with a risk of malignancy estimated between 5 and 15%. Endocrinopathies are some...

Objective: Study of the efficacy of SSA in the biochemical and tumour control and the relation between the T2-weighted MRI signal intensity and the response to SSA.Material and methods: 16 patients with GH-secreting pituitary adenomas (7♂/9♀) that received primary or pre-operative treatment with SSA. We classified them according to baseline T2-weighted MRI sequences as Hypo-intense (Ha) and No-Hypo-intense adenomas (no-Ha). Results expressed ...

Aim: To describe the clinical and analytical characteristics of patients with hypopituitarism in the Endocrinology Department.Materials and methods: This was a descriptive, retrospective study with 70 patients diagnosed with hypopituitarism in the Endocrinology Department´s outpatient consultations with a follow-up of up to 44 years. The qualitative variables were expressed in frequencies and the quantitative variables showed a normal distribution e...

Immune-checkpoint inhibitors have been increasing used in the field of medical oncology for treatment of various early to late-stage malignancies, however, rare occurrences of adrenal insufficiency and thyroid dysfunction may occur. Pembrolizumab, a PD-1 inhibitor, has been associated with adrenal insufficiency in 1-2% of patients, while thyroid related adverse events occurred in 3.2-10.1%. This is a case report of an 81 year-old male, known to have a cutaneous melanoma stage ...