Endocrine Abstracts

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Thyroid hormone (TH) is a major determinant of muscle physiology, and thyroid dysfunctions are leading causes of many myopathies. Precise control of thyroid hormone-dependent transcription is required by multiple cell system, including muscle stem cells, but how this is achieved is still largely unknown. Intracellular TH concentration is determined by a metabolic balance between the activating and inactivating deiodinase enzymes, D2 and D3. In functional combinations, these re...

MicroRNA (miRNAs) are small non-coding RNA molecules that significantly impacted the understanding of cell biology in the last decade. They regulate the expression of 10–30% of all protein-coding gene, thus playing a crucial role in a wide range of biological and pathological processes. Consistently, aberrant miRNA expression has been implicated in numerous human diseases, including pituitary tumours. Different studies analysed the entire miRNA transcriptoma, by microarra...

HMGA2 gene amplification and overexpression in human prolactinomas and development of pituitary adenomas in HMGA-transgenic mice showed that HMGA proteins play a crucial role in pituitary tumorigenesis. Recently, we have explored the pRB/E2F1 pathway to investigate the mechanism by which HMGA proteins act, showing that HMGA2 interacts with pRB and induces E2F1 activity in mouse pituitary adenomas by displacing HDAC1 from the pRB/E2F1 complex – a process that result...

Patients with gonadotoxicity due to disease treatment, or who face primary gonadal insufficiency as a result of genetic causes, have limited options for long-term endocrine and fertility support. Current fertility options, such as egg or embryo banking, exclude women with hormone-responsive cancers and pre-pubertal children. This highlights the urgency of addressing this currently unmet need with innovative engineering solutions. Our objective is to create an ovary bioprosthes...

Increased waist circumference is a cardiovascular risk factor, currently we have the cutoff value of International Diabetes Federation (IDF) or by Latin-American standards; in Colombia has not studies where showing the relationship between increased waist circumference and the risk of diabetes. This study aims to show the relationship between increased waist circumference by IDF criteria or Latin-American criteria and the risk of diabetes.Methodology: Cr...

Long-standing primary failure of pituitary-dependent endocrine glands may induce pituitary hyperplasia and adenoma both related to duration and severity of peripheral gland insufficiency, although the formation of an adenoma is rare. We report the case of an elderly man with pituitary macroadenoma but compensated adrenocortical failure. A 70-year-old man referred our centre in 2013 for headache and horizontal diplopia. MRI revealed pituitary macroadenoma (1.9×1.1×2.2...

Introduction: Pheochromocytomas are neuroendocrine tumors derived from chromaffin cells which secrete catecholamines. Cushing syndrome due to ACTH-secreting pheochromocytomas is a rare condition and early recognition and treatment is important to decrease morbidity and mortality.Case presentation: We present the case of an 53 years-old man who arrived at the hospital for pain in the right scapula agravated in the last three months with iradiation in the ...

There is little evidence of glycaemic control changes in Paediatric patients with diabetes during pandemics or natural disasters. We were interested in analysing and comparing the HbA1c values in children and young people with diabetes at West Hertfordshire NHS trust before the covid-19 pandemic in 2019-2020 and during lockdown in 2020-2021. Our hypothesis was that there would be a deterioration in HbA1c outcomes and a reduction in the number of tests done in 2020-2021. We ass...

Introduction: To systematically evaluate the study designs and the outcomes being analysed in the ongoing trials evaluating the efficacy and safety of Insulin Glargine 300 U/ml with insulin degludecMethods: We reviewed contemporary protocols of trials that are currently ongoing through WHO-ICTRP (www.who.int/ictrp/search/en), www.clinicaltrials.gov trials registry database. Latest evaluation was on January 28, 2022 with key word ‘insulin galrgaine U...