Endocrine Abstracts

Olfactory neuroblastoma (ONB) is a rare neuroendocrine tumour arising within the sino-nasal cavity. It occurs world wide, affecting both sexes, all ages and all races with no underlying predilection having yet been identified. ONB exhibits a range of phenotypes from indolent to very aggressive, and up to 5% cases are associated with ectopic hormone secretion. Despite current gold-standard treatment of surgical resection (either endoscopic or craniofacial resection) followed by...

Introduction: Obesity caused health problems are increasing. Metabolic syndrome including obesity with insulin resistance, hypertension, and high blood lipid levels increases the risks of cardiovascular and inflammatory diseases. Many studies have reported that heme oxygenase (HO) inducers reduce insulin resistance and severity of inflammatory bowel disease. We investigate the anti-inflammatory effect, one among many positive effects, of regular recreational physical activity ...

Introduction: Physical inactivity, i.e. sedentary life style increases circulatory disease risk. Carbon monoxide and nitric oxide produced by the heme oxygenase (HO) and by the constitutive nitric oxide synthase (cNOS) protect circulation. In contrast, the enhanced level of the matrix metalloproteinase (MMP) augments cardiovascular risks. We examined the actions of recreational physical exercise on the expression of these enzyme systems in conjunction with cardiovascular prote...

Introduction: Selective oestrogen receptor modulators function as oestrogen receptor antagonist in the breast and gonads, while they have agonistic effects on the bone and the cardiovascular system. It is also known that endogenously produced carbon monoxide by the heme-oxigenase (HO) enzyme exerts beneficial actions in cardiovascular protection.Design: Intact females, ovariectomized (OVX), raloxifene or oestrogen treated OVX Wistar rats were used. We st...

Introduction: In the human, obesity is one of the leading health problems as declared by the World Health Organization. Obesity is frequently associated with diabetes, hypertension and hyperlipaemia, these acts together as metabolic syndrome (MS). The risk of cardiovascular diseases is 5 to 10 times higher in MS. Lack of daily exercise is a good reason to evolve MS. Several hormones take part in the development of MS. Leptin and insulin, which are produced by the adipose tissu...

Overview: Despite marked insulin resistance, patients with active acromegaly have low hepatocellular lipid content (IHL) and an unfavourable hepatic lipid composition (UI). As previously shown, inadequate mitochondrial activity in the liver might counteract lipid accumulation in the liver. The purpose of this study was to understand changes in hepatic metabolism, and lipidomic profile with therapy of acromegaly.Methods: We prospectively included thirteen...

Context: The role for hormone parameters at adrenal venous sampling (AVS) in predicting clinical and biochemical outcome remains controversial.Objective: To investigate the impact of hormone parameters at AVS under cosyntropin stimulation on lateralization and on complete biochemical and clinical outcome.Methods: We retrospectively evaluated 168 sequential AVS under cosyntropin infusion. Bilateral successful cannulation rate was 83...