Endocrine Abstracts

Primary hyperparathyroidism (PHPT) is the third most frequent endocrine disorder and has a variable clinical presentation. Asymptomatic PHPT became the predominant form of the disease with increase of it’s incidence after the introduction of automated serum calcium measurement in North America and Europe. Data from Russia is lacking.Aim: To present the clinical profile of PHPT in Russia.Materials and methods: This retrospectiv...

Introduction: Patients with primary hyperparathyroidism (pHPT) run an increased risk of death, and in some studies cardiovascular diseases were inversely related to urine osmolality.Aim: Evaluate the renal concentration capacity in patients with mild and severe pHPT, and its changes after surgery for pHPT and during medical management and monitoring.Materials and methods: The study included 77 patients (median age 57 (52;61)) with ...

Objective: Primary hyperparathyroidism (PHPT) is one of the most frequently diagnosed endocrine disorders. The Russian Registry of PHPT is an on-line web-based database created in 2016 with the aim to estimate the disease prevalence and improve the quality of health care for such patients in Russian Federation. The Endocrinology Research Centre, Moscow represents The Head organization.Material and methods: We retrieved retrospective data submitted to the...

: Rarely PHPT could be a part of MEN 1 (2–4.5%). Little is known about clinical differences between MEN1 related and sporadic PHPT.Aim: To compare the clinical features of PHPT in MEN type 1 cases and sporadic PHPT.Materials and methods: Data were obtained in 442 patients: 62 sharing MEN1 phenotype (PHPT in association with pituitary adenomas and/or gastroenteropancreatic neuroendocrine tumors) (Group-I) and 380 with apparentl...

Background: Hypertension is one of the widespread cardiovascular pathology in patients with primary hyperparathyroidism (PHPT).The renin-angiotensin-aldosterone system (RAAS) is a key system in the regulation of blood pressure and its interactions with mineral metabolism are described. Our previous study* of PHPT patients revealed a significant decrease in plasma renin activity (PRA) and serum aldosterone levels in the early postoperative period and also positive correlations ...

Background: Parathyroid cancer (PC) is a rare tumor associated with poor prognosis particularly when disseminated. Currently, the only effective treatment is a surgical intervention.Case: Starting from the age of 19 a woman had been suffering from bone pains and change in gait. A low-energy right humerus fracture with displacement occurred when she was 23. At the same time, primary hyperparathyroidism (PHPT) was diagnosed for the first time (PTH 569 pg/m...

Introduction: Primary hyperparathyroidism (PHPT) results in alterations in carbohydrate metabolism, characterized by insulin resistance, hyperinsulinemia, and glucose intolerance.Objective: The aim of our study was to evaluate carbohydrate metabolism status in patients with PHPT.Methods: One hundred and nine patients with PHPT were investigated, healthy controls included 36 individuals matched by sex age and BMI (BMI=27±5 kg/m...

BackgroundMost cases of primary hyperparathyroidism (PHPT) is caused by a single benign adenoma, multiple parathyroid neoplasms (MPN) occur less often in 10–15%, parathyroid carcinoma accounts for <3%. MPN can be sporadic or develop due to inherited genetic syndromes (most commonly multiple endocrine neoplasia syndrome type 1 (MEN-1) that usually manifest at a young age. The preoperative examination of patients with MPN is important for achievin...

Background: Secondary hyperparathyroidism (SHPT) is an early complication of chronic kidney disease (CKD). Maintaining the level of 25(OH)D and parathyroid hormone concentrations in the target range reduce its associated complications (fractures and cardiovascular calcification).Aims: To examine the effectiveness of vitamin D supplementation and selective vitamin D receptor agonists treatment on SHPT in CKD.Materials and methods: P...

Background: Parathyroid cancer (P?) in children is extremely rare, more often sporadic, but may be associated with a germline mutation. The only effective treatment is surgical approach due to the chemo-radio-resistance of PC.Clinical case: A 6-years-old girl presented with weakness, gait disturbance, pain in the limbs, an X-shaped curvature of the legs. At the age of 12, the patient’s well-being worsened sharply. The laboratory examination revealed...