Endocrine Abstracts

Aim: To investigate the impact of overall obesity (Ob) and diabetes mellitus type 2 (DM2) on arterial stiffness and degree of insulin resistance in patients with arterial hypertension (AH) and abdominal Ob (AOb).Design and method: 74 subjects were divided according to presence of AH, AOb, Ob, and DM2 without insulin therapy. Control group 1 consisted of 26 subjects without AH, AOb, Ob, and DM2. All patients with AH were also diagnosed with AOb and amount...

Ghrelin is known to play an important role in overweight formation and glucose metabolism regulation. The aim was to assess ghrelin basal secretion features in persons with metabolic syndrome (MS).We examined 39 patients (age 35–55years) with MS (IDF criteria) and 28 healthy persons of comparable age. Ghrelin, insulin and C-peptide serum concentrations were measured by immunoenzyme method, lipid spectrum parameters - by spectrophotometry. For IR ass...

It’s well known that secondary hyperparathyroidism (SHPT) is common in patients with chronic kidney disease stage 5 (CKD5D), on dialysis. The aim of our study was to analyze peculiarities of SHPT in diabetic patients in comparison to those with other course of CKD5D.We studied 25 diabetic and 180 non-diabetic patients with CKD5D, mean age 47.5±10.8 years; age at dialysis onset 42.7±11.7 years; dialysis duration 4.7±3.9 years. Groups w...

Introduction: Nowadays polycystic ovarian syndrome (PCOS) appears to be one of the most common endocrine disorders that involves from 5 to 10% of women of reproductive age, reaching 75% in the structure of endocrine infertility. Furthermore the distribution of adipose tissue in android region correlates with the prognosis of diabetes, metabolic syndrome and cardiovascular diseases development.Aim of the study was to determine the type of obesity and to d...

Objective: To assess glucose metabolism (GM) parameters before and after vitamin D treatment in pre-diabetic women.Material and Methods: In the study were included fifty eight women with prediabetes (impaired fasting glucose (IFG) or impaired glucose tolerance (IGT)) aged from 40 to 55 with signed informed consent. The study didn’t include women with diseases affecting the vitamin D metabolism, as well as women receiving regular vitamin D supplemen...

Aim: Is to determine the frequency of hypoglycemic states in patients with T1DM with and without depression.Materials and Methods: patients with T1DM (57 men and 51 women) aged 41.15 years (34.65, 46.66) were examined, with the experience of diabetes about 11.32 years (2.80, 11.90). Depression was determined according to the scale HADS. Assessment of glycemia was carried out with the help of daily monitoring system of glucose in intercellular fluid (CGMS...

Aim: To determine the relationship between C-reactive protein (CRP) and nephropathy in type 1 diabetic patients.Methods: A total of 68 patients (24 women and 44 men) with type 1 diabetes aged 46.58±12.23 years were studied. All subjects had BMI<35 kg/m2. The levels of CRP, fasting blood glucose (FBG), triglycerides (TG), HbA1c and renal function tests were assessed. Patients were divided into 2 groups: 1 group – patients with nep...

Aim: To determine the relationship between serum lipids with albuminuria in patients with type one diabetes.Methods: A total of 150 diabetic patients both sexes aged 41.58±11.33 years were studied. The levels of total cholesterol (TC), triglycerides (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), VLDL-cholesterol (VLDL-C), HbA1c and renal function tests were assessed. Patients were classified as normoalbuminuric (albumin excretion...

Aim: To study the effect of testosterone replacement treatment in the aging male with T2DM.Material and methods: Twenty-six hypogonadal men with T2DM and late-onset hypogonadism (Total testosterone at diagnosis <12 nmol/l) between the age 50–65 years (55.00 (50.00;58.00)) were treated with a 1% testosterone gel (AndroGel) (5 g/day) within 6 months. Patients were assessed before the first using of AndroGel, in one week interval and in 6 months. A...

Aim: To clarify the contribution of leptin to bone mineral density (BMD) in men with type 2 diabetes mellitus (DT2).Materials: We screened 168 Belorussian men aged 50–65 years. Plasma TC, HDL-C, LDL-C, VLDL-C, TG concentrations, HbA1c, IRI, CRP, total testosterone were assessed. BMD was evaluated using dual-energy X-ray absorptiometry (DXA). BMD was expressed as a T score. All statistical analyses were performed using SPSS v11.0 software....