Endocrine Abstracts

The hippocampus is majorly involved in memory formation. The insulin pathway regulates the level of GSK-3β, which is involved in the formation of amyloid beta and Tau. Allium sativumhas been shown to reduce amyloidogenesis and increase brain insulin sensitivity. 32 male Wistar rats were used in this experiment. They were grouped into 4, each with 8 rats. Group A (Sham), B (3 mg/kg of streptozotocin), group C (3 mg/kg of streptozotocin +300 mg/kg of Allium sat...

Case report: A 55 years old Caucasian gentleman presented with recurrent episodes of unexplained hypoglycaemia with slurred speech, lethargy, myoclonic jerks and seizures. He had background of craniopharyngioma at the age of 17 and underwent surgery but no radiotherapy. Subsequently he was started on hormonal replacement with desmopressin, levothyroxine, hydrocortisone, testosterone and genotrophin and remained stable on treatment for 38 years. Hypoglycaemia work up revealed b...

Alzheimer’s disease (AD) development has a direct relationship with Brain-insulin resistance. Central in the pathology of AD are beta-amyloid and tau proteins associated with cognitive decline in the hippocampus. Allium sativum L. has been shown to have a neuroprotective effect. Thirty-two male Wistar rats (80-150 g) were assigned into A-D (n=8 each), and housed in standard plastic cages at 23± 1°C. Group A received saline, groups B and C were ad...