Endocrine Abstracts

Background: The balance between Adrenergic Receptor (AR) subtypes and Atrial Natriuretic Peptide (ANP) is crucial for lipolysis. It was previously demonstrated that ANP is strongly lipolytic and we recently demonstrated that ANP is expressed and secreted by human pre-adipocytes. In previous studies, β-receptor density and lipolysis were higher in human visceral adipose tissue (HVAT) as compared with human subcutaneous adipose tissue (HSAT).Aims and ...

Heterozygous germline gain-of-function mutations of the extracellular calcium-sensing receptor (CaSR), a G-protein coupled receptor (GPCR), result in autosomal dominant hypocalcaemia type 1 (ADH1), which may cause symptomatic hypocalcaemia with low circulating parathyroid hormone (PTH) concentrations and hypercalciuria. Negative allosteric CaSR modulators, known as calcilytics, rectify the gain-of-function caused by CaSR mutations and are a potential targeted therapy for ADH1....