Endocrine Abstracts

Although androgen insensitivity syndrome (AIS) is commonly suspected as a cause of a 46,XY disorder of sex development (DSD), only about half of these cases can be attributed to an inactivating mutation within the coding sequence (CDS) of the androgen receptor (AR) gene. This led to the hypothesis that disrupted AR activation in AIS may also be caused by a defect in a co-factor of AR-activity. However, so far mutations in AR co-factors leading to AIS have not been ide...

Due to the increased availability and use of radiology, endocrinologists are referred patients with incidentally discovered, clinically silent adrenal masses with increased frequency. Controversies persist regarding their investigation and management. We present two cases focusing in particular on the role of radiology in the management algorithm.A 43-year-old male underwent a CT urogram, which revealed an incidental 3×3×2 cm right adrenal mass...

Osteoporosis is a debilitating condition that can be prevented by timely detection and treatment. Detection requires referral for dual energy X-ray absorptiometry (DXA) that depends on risk factors. We estimated the importance of risk factors for a T-score of <−2.5 measured by spine and hip DXA in all men and women referred from general practice for a DXA scan at Aalborg University Hospital during a 3 years period. Risk factors were assessed by questionnaire...

Worldwide, a care gap has been recognized between presenting with a fragility fracture and prevention of the next fracture. Fracture Liaison Service is the most cost-effective method to close this gap, but its implementation is sparse in many countries. To assess the need for a subsequent fracture prevention program in Denmark, we conducted a cross-sectional study – named OFELIA - aiming to estimate the prevalence of osteoporosis in a Danish cohort of fragility fracture p...

Less than 0.5% of parathyroid lesions are cysts out of which only 10–20% are endocrine active. Depending on their localisation, the most frequent symptom of a parathyroid cyst (PC) is neck mass (41.7%) with possible compressive symptoms. Women are more frequently affected and tend to have hormone-inactive PCs. Men tend to have endocrine-active PCs. The best diagnostic approach is still under debate as PCs are relatively rare.Case report 1: A 68-year...

Background/aims: Oxidative stress and inflammation play a role in development of diabetic kidney disease. Postprandial hyperglycemia and hyperlipidemia are speculated to be associated with increased oxidative stress and inflammation. The aim was to examine the effect of meal composition on post-prandial risk markers for kidney disease among those with type 2 diabetes (T2D) and healthy subjects (HS).Material/methods: On four occasions 21 patients with T2D...

Objectives: TSH-producing pituitary adenomas account for 1–2% of all pituitary tumors and there is debate wether transsphenoidal surgery or medical treatment should be recommended as first-line treatment. This study summarizes the authors surgical experience and puts it into context of literature concerning non-surgical treatment of TSHomas.Methods: A retrospective analysis of 12 patients including imaging, laboratory testing, short-term and long-te...

Background: Recent guidelines recommend lobectomy (LOB) when compared to total thyroidectomy (TTX) as the preferred approach for patients with low-risk differentiated thyroid cancer (DTC). Major advantages are the avoidance of lifelong hormone replacement therapy and the absence of any risk for contralateral recurrent laryngeal nerve palsy and postoperative hypoparathyroidism with no or minimal increased risk for adverse oncological outcomes. However, this limited approached s...

Background: Focused parathyroidectomy has become the standard procedure for patients with sporadic primary hyperparathyroidism (pHPT) fulfilling the criteria for surgical therapy and requires preoperative localization procedures. Ultrasound imaging (US) and 99mTc-sestamibi-scintigraphy with/without SPECT/CT (SC) are established first line procedures. 18F-choline PET/CT (PET) has emerged as a novel sensitive and specific method. However, current reimbursem...

Introduction: Thyroid autoimmunity has been associated with pregnancy loss. A possible mechanism is an overactive maternal immune system leading to rejection of the fetal allograft. In women with recurrent pregnancy losses (RPL), we investigated the association of thyroid peroxidase antibodies (TPOAbs) with number of losses and outcome of first pregnancy after referral.Methods: Prospective study of women with RPL (≥3) followed at the RPL Unit, Cope...