Endocrine Abstracts

Variants of ADIPOQ have been inconsistently associated with adiponectin level in diverse populations. We explored association of single nucleotide polymorphism (SNP) in the ADIPOQ (+276 G>T, rs1501299) with circulating total adiponectin and insulin resistance (IR) in Ukrainian T2DM cohort.Materials and methods: 544 T2DM patients (M/F: 241/303, age 56.3±0.4 years, diabetes duration 7.8±1.0 years, BMI 31.7&...

Background and aimThe epidemic of overweight and obesity presents a major challenge to chronic disease prevention and health across the life course around the world. The putative relationships between thyroid hormones, body weight, and adipose tissue homeostasis have been the focus of several studies in recent years, but the causal relationships between these parameters have not been well established. Aim of the study: to investigate the relations...

The aim of the study: Laparoscopic sleeve gastroectomy is now the gold standard for bariatric surgery for the treatment of obesity and metabolic syndrome. Laparoscopic gastroplasty is a relatively innovative procedure that has recently been used throughout the world. The purpose of the study was to assess the perioperative safety and outcome of procedures in 2 years.Materials and methods: Sixty two patients with a body mass index of 35 kg/m2 t...

To date, up to 35% of the young population (25–60 years) in developed countries are subject to anxiety disorders. The use of anti-anxiety agents in clinical practice does not always lead to a lasting effect. The study included patients who initially consulted a neurologist or psychotherapist. With panic attacks. On the Anxiety and Depression Rating Scale (HADS), all patients received 11 points or more. The use of anti-anxiety drugs gave a short-term effect with subsequen...

Introduction: Recently, vitamin D3 (cholecalciferol) deficiency has been considered as one of the factors for the development of type 2 diabetes mellitus (T2D) and metabolic syndrome (MS), which contributes to increased insulin resistance (IR) and reduced insulin secretion. The most pronounced vitamin D deficiency is observed in persons suffering from morbid obesity. The aim of this study was to assess IR, b-cell functional activity and metabolic profile parameters according t...

Introduction: LADA exhibits characteristics of both type 1 diabetes mellitus (DM) and type 2 DM. Patients with LADA usually have some components of metabolic syndrome. GLP-1 agonists have been widely used in type 2 DM. GLP-1 agonist therapies have shown some promising glucose lowering effect in T1DM. Almost no information is available on glucagon and incretin secretion in patients with LADA as well as effects on glucose and C-peptide levels.Case report: ...

Objectives: The number of reported cases COVID-19 associated subacute thyroiditis (ST) in literature is small thus peculiarities of its clinical features remain the subject of interest. The aim of the review is to share our experience of COVID-19 associated ST.Materials and Methods: We describe 5 cases of COVID-19 associated ST. SARS-CoV-2 diagnosis was based on the presence of its typical symptoms and real-time polymerase chain reaction on nasopharyngea...

Background and aims: There is compelling evidence that the decline in appendicular muscle mass is a poor prognostic factor for the development of chronic complications of diabetes. In addition to chronic hyperglycemia, reduction of muscle component may be determined by metabolic disorders. Therefore, the aim of study was to assess the possible links between serum myostatin, IGF-1 and a reduction in muscle mass in type 1 diabetes mellitus (T1DM).Materials...

Brain tumors are on the 3rd place in terms of growth rates of incidence among oncological diseases. By virtue of the improvement of neurosurgical treatment methods, with the use of modern chemotherapy and radiation therapy, the survival of patients with benign and malignant brain tumors is increasing. A significant proportion of patients with such tumors are young people of reproductive age who are interested in maintaining their fertility. Neurosurgical removal of tumors, whi...

Aim: To investigate the clinical efficacy of the treatment of patients with neuro-ishemic diabetic foot ulcers (DF) by using sorption-antimicrobial nanocomposition based on silica sorbents.Methods: Hydrophobic-hydrophilic sorption-antibacterial nanocomposition, offered for the treatment of ulcers and wounds, contains sorbents (nano-disperse silicon dioxide, polymethylsiloxane) and antibacterial components (decamethoxin, metronidazole). In this study 78 p...