Endocrine Abstracts

Introduction: Bisphosphonates therapy is the standard of care in postmenopausal osteoporosis. In the HORIZON-RFT, annual i.v. Zoledronic acid (ZOL) 5 mg infusion significantly reduced the rate of new fractures by increased bone mineral density (BMD). We proposed to evaluate the effect of ZOL treatment in BMD change in a group of postmenopausal osteoporotic women assessed by DXA–BMD. We have proposed also to assess the adverse events of this treatment.<p class="abstext...

IntroductionLeukocyte recruitment is a key feature in (I/R)-induced tissue injury. We have developed and validated a novel method to study molecular mechanisms of leukocyte-endothelium interactions in the colonic microcirculation in vivo by use of inverted intravital fluorescence microscopy.Methods & ResultsIn male C57/BL6 mice the superior mesenteric artery was occluded 30 min and leukocyte rolling and ...

The TSH B/I ratio is normally reduced overnight and is substantially reduced in patients with overt central hypothyroidism due to h-p axis tumours before and after treatment. It is unknown if similar changes in the TSH B/I ratio in the absence of overt central hypothyroidism contribute to the increased TSH levels seen in cancer survivors who undergo h-p axis irradiation. Thus, we selected 9 patients with the highest TSH levels out of a previously reported cohort of 37 euthyroi...

Introduction: The clinical implications of QTc and P wave dispersion in patients with Cushing’s syndrome have not been studied previously. In this study, we aimed to compare QTc dispersion and P wave dispersion in patients with Cushing’s syndrome and healthy subjects.Material and method: Sixteen patients with Cushing’s syndrome diagnosed on clinical, laboratory and imaging findings and 16 age and sex matched control subjects were included....

Selenium (Se) is an essential trace element and is important for maintaining health and preventing disease. Se exhibits its biological function as the 21st proteinogenic amino acid selenocysteine (Sec). Different cis and trans acting factors are necessary for incorporation of Sec into proteins. Se can be transported and stored as Sec in selenoprotein P (SePP), a liver-derived protein which contains up to 10 Sec residues per protein in humans. Thus, SePP functions...

Introduction: The serum calcium/phosphorus (Ca/P) ratio has been proposed to identify patients with primary hyperparathyroidism and chronic hypoparathyroidism (HPT) from healthy subjects. However, other disorders of the Ca-P metabolism might present similar biochemical profile of HPT, such as pseudohypoparathyroidism (PHP), for which the use of Ca/P can be useful. Aim: To test the performance of Ca/P ratio in the diagnosis of PHP in comparison to healthy...

Background: D hypovitaminosis and primary hyperparathyroidism frequently coexist. Secondary hyperparathyroidism reactive to D hypovitaminosis is difficult to be differentiated from primary hyperparthyroidism.Aims: To differentiate patients with D hypovitaminosis and secondary hyperparathyroidism.Materials and methods: Prospective study involving 71 patients admitted in our department for 1 year with the initial diagnosis of primary...

Background: Vitamin D deficiency is frequently associated with primary hyperparathyroidism, but the impact of this association on disease evolution and complications is ill defined. Aims: to assess the role of vitamin D status on the metabolic profile and spectrum of complications at patients with primary hyperparathyroidism.Materials and methods: Transversal study involving 42 patients with primary hyperparathyroidism submitted to parathyroidectomy. We ...

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder that is characterized by hypercalcemia and elevated or normal levels of parathyroid hormone (PTH). Most PHPT cases are incidentally discovered when routine laboratory analysis reveals hypercalcemia. PHPT should be considered in any person with elevated serum calcium (Ca) levels and no clear evidence of malignancy. Serum phosphorus (P) is low due to the phosphaturic effects of PTH and mostly in the ...

Background: Primary hyperparathyroidism (PHPT) is the third most common endocrine disorder. The Ca/P ratio is an accurate tool to differentiate patients with PHPT (>3.5 if Ca and P are expressed in mg/dl) from healthy subjects [1]. The reliability of this index is based on the fact that serum Ca and P are inversely related together. However, other disorders of the Ca-P metabolism, such as hypophosphoremia (HypoP), might impair the Ca/P ratio.Aim: To ...