Endocrine Abstracts

Introduction: Patients with acromegaly have increased mortality, primarily related to cardiovascular/cerebrovascular disease. The objective of this study was to evaluate whether GH/IGF-1 excess increases vascular disease by adversely affecting fibrin network characteristics.Methods: In this case–control study, 40 patients with acromegaly (21 males, age 53±13 years, 45% disease remission) and 40 age and gender-matched controls were recruited. Cl...

Determining the sequence of events controlling preadipocyte commitment and subsequent terminal differentiation into adipocytes is critical to gain insight into brown and white fat physiology and metabolic dysfunction. MicroRNAs (miRNAs) are important regulators of gene expression and emerging evidence supports their involvement in adipogenesis and adipose metabolism. The aim of this study is to 1) identify miRNAs that modulate differentiation or function of white and brown adi...

Improved knowledge of adipogenesis is necessary to gain insight into brown and white fat physiology. Interest in adipocyte differentiation has increased markedly over the past few years with emphasis on intersection between microRNAs (miRNAs) and the transcriptional cascade that controls adipogenesis and metabolic dysfunction. The aim of this study is to identify miRNAs that regulate white and brown adipocyte differentiation and define miRNA action in a stem cell model of adip...

Introduction: Worldwide, diabetes is a common metabolic disorder that creates many complications. Nowadays a mobile-based application could be included in the therapeutic approaches of self-management.Aim: This study presents the development of a mobile application named ‘Diabetes 2 Learn’ for people with type 2 diabetes inside the Greek population.Methods: Google Play and App Store were examined for their apps on diabete...

Introduction: The mobile health (mHealth) technologies use mobiles and also wireless network and devices to offer services for improving health, promoting behavior changes and supporting self-management. The increasing global use of mobile application (app) is widely accepted in managing chronic diseases and especially among people with type 2 diabetes mellitus (T2DM).Aim: The purpose of this study was to identify the impact of the interventions based on...

Introduction: Early menopause (defined as age of menopause <45 years) and premature ovarian failure (defined as age of menopause <40 years) are associated with accelerated bone loss and increased risk of osteoporosis in later life. However, their association with increased fracture risk has not been established, with studies yielding conflicting results. The aim of this study was to systematically review and meta-analyze studies evaluating the effect of age at onset of...

Background CPHD is characterized by GH and at least one other pituitary hormone deficiency. Mutations in genes expressed in the developing head, hypothalamus, and/or pituitary cause CPHD. To date around 30 genes have been identified to be related to CPHD, however 85% of the cases remain with unknown molecular aetiology.Patient and methodsA newborn boy (46, XY) delivered by CS due to IUGR with a birthweight of...

IntroductionMenopausal transition is associated with an increase in the cardiovascular risk, possibly related with the sharp decrease of estrogen levels. Menopausal symptoms and more specifically hot flushes have been previously linked with an increase in cardiovascular risk. On the other hand, non-alcoholic fatty liver disease is considered as another presentation of the metabolic syndrome, conferring additional cardiovascular risk to the affected indiv...

Case history: 48 year old man presented in the endocrinology clinic for further evaluation of hypertension (HTN). He had a hospital admission 2 months ago with worsening dyspnoea and markedly elevated BP (236/149 mmHg). He denied any visual disturbances or chest pain. There were no symptoms to suggest any endocrinopathy. His PMH included previous inguinal hernia repair. He was not on regular medications and he had no allergies. He lived with his family, worked as a manager and...

Introduction: We describe a case of a 29 year old man who was referred to endocrinology services with a 4 month history of erectile dysfunction, decreased libido and low testosterone. He denied symptoms suggestive of pituitary pathology. And he had no previous testicular infections or trauma. His past medical history included asthma, which was well controlled with b-agonist inhaler as required. He had normal development. He was a non smoker, abstinent from alcohol and a keen c...