Endocrine Abstracts

Objectives: Craniopharyngioma is a benign tumour of the suprasellar region that is associated with increased morbidity and mortality in comparison to other causes of hypopituitarism. We aimed to establish the mode of presentation, investigations, treatment outcomes, mortality and subjective improvement in patients with craniopharyngioma in a single institution over 10 years.Design: Retrospective case notes review of patients with Craniopharyngioma on end...

Introduction: We submit a rare presentation of round blue cell pituitary tumour complicated by cranial diabetes insipidus following transphenoidal surgery.Case history: 47-year-old lady with severe headache was diagnosed with a 10 mm non functioning pituitary macro adenoma. Initial plan for conservative management was revised as she developed sixth cranial nerve palsy, bi temporal hemianopia and rapidly enlarging pituitary tumour to 20×18×19 mm...

Efficacy and Safety of High Dose Testosterone Therapy in Partial Androgen InsensitivityS. Bandyopadhyay, W.A.Watson, C. M.Park, P. Abraham, S. Philip, S. Acharya , J.S. Bevan. Department of Endocrinology, Aberdeen Royal Infirmary, Aberdeen, AB25 2ZN.INTRODUCTION: There have been few reports of the efficacy and safety of high dose androgen therapy in men with partial androgen insensitivity (PAI). We report on the responses of a p...

Introduction: We present a case of probable cyclical Cushing’s syndrome (CS) masquerading as polycystic ovarian syndrome (PCOS) which went undetected for almost a decade. Our case highlights the subtleties and complexities of interpreting diagnostic tests in patients with cyclical endogenous hypercorticolism.Case: A 33-year old female with presumed PCOS presented with a seven year history of persistent hirsutism and acne. However there was no menstr...

Introduction: Giant prolactinomas are uncommon tumours and typically exceed 40 mm. These tumours are locally invasive but still respond to dopamine agonist therapy. The medical management of cystic giant prolactinomas with dopamine agonists is controversial as the non-solid components of these aggressive tumours are believed to respond poorly to drug therapy. We present a case of a giant cystic invasive prolactinoma masquerading as a multilobular schwannoma that was successful...

IntroductionIsolated TSH (thyroid stimulating hormone) deficiency has been reported in the literature as a rare condition. Only 60 cases have been reported so far since 1960. It has been defined as central hypothyroidism without evidence of any other pituitary hormonal deficiencies or evidence of any structural pituitary abnormality. We report 3 cases of suspected isolated TSH deficiency, 2 of which presented in a year to one endocrine centre.<p clas...

The 68Ge/68Ga generator has the potential to greatly expand positron emission tomography (PET) imaging to benefit more patients, by allowing many PET applications in hospitals without immediate access to cyclotrons and costly radiochemistry facilities. It is often suggested that ‘68Ga is the new 99mTc,’ drawing parallels with conventional radiopharmacy practice where radiopharmaceuticals are prepared with little more complex equipment than a syr...

The human tachykinin, endokinin (EK), is processed into a 41mer in the human placenta. As synthetic EK(10–41) is as potent as substance P at the NK1R, it is likely that the primary function of EK is as the principal placental NK1R agonist mediating local beneficial vasodilatation. Although the emetic and sialogogic actions of substance P are well known, its complete absence from the placenta probably explains why its role in pregnancy has not been studie...

Non-alcoholic fatty liver disease is a condition characterised by deposition of fat within the liver and can be associated with progressive inflammation and fibrosis (NASH). Up to 30% of the population may have NAFLD and yet only a small proportion will have progressive disease. This means that accurate stratification of at risk patients is required to ensure best use of NHS resource. The talk will describe the diagnostic modalities that can be used to identify patients includ...

24 years old gentleman presented with 6 months history of nausea and occasional vomiting after eating, night sweats and pain on left side of abdomen. CT abdomen and pelvis showed left sided retroperitoneal mass measuring 6.3×5.8×8 cm with lying BP 120/100 and standing 140/100 pulse 100 per min Urinary noradrenaline was 27732 nmol/24hour. Repeat urine noradrenaline shown 12479 nmol and 13505 nmol/24hr. MIBG showed tumour on left upper abdomen with no uptake in the lun...