Endocrine Abstracts

Purpose: Primary hyperparathyroidism (PHPT) is the third common endocrine disorder which often manifest with skeletal or renal disfunction. In developed countries asymptomatic form is the most common and such severe manifestations as osteofibrosis cystica are very rare.Clinical case: We present the case of 49-years-75 × 66 old caucasian woman, with history of urolithiasis, nephrolithotripsy in 2014. In November 2016 she was diagnosed with left femur...

Background Fibrocystic osteitis is rare PHPT manifestation. Poor management and delay in diagnosis of fibrocystic osteitis may lead to reduced quality of life and also provoke severe postoperative hypocalcemia – «hungry bone» syndrome.Clinical case We present a case of 66-years-old Caucasian woman, with history of urulithiasis/nephrocalcinosis (CKD stage 4), two pathological fractures, and fibrocystic osteitis. In Jan 2021...

Background: Management of primary hyperparathyroidism (PHPT) in Multiple Endocrine Neoplasia type 1 syndrome (MEN 1) is still a challenge. PHPT developing in MEN 1 is characterized by the involvement of all parathyroid glands. Therefore, by modern guidelines, total or subtotal removal of the parathyroid glands is recommended. But this approach often leads to the development of hypoparathyroidism, adequate correction of which is not always possible. Drug therapy of recurrent PH...

BackgroundPrimary hyperparathyroidism (PHPT) is the third most common endocrine disorder mainly caused by a single parathyroid adenoma. The localization of the parathyroid adenoma is useful for increasing the recovery rate of PHPT, and reducing the complication rate. Conventional localization techniques include neck ultrasound, Tc99m-MIBI-SPECT and CT. However, each one of those has its limitations; particularly in cases of ectopic, or multiple parathyro...

Background : Parathyroid tumors are considered to be parathyroid neuroendocrine neoplasia (NEN), according to the recent IARC-WHO classification updates. Primary hyperparathyroidism (PHPT) develops commonly in patients with multiple neuroendocrine neoplasia syndromes (MEN), when it occurs along with pituitary, gastro-entero-pancreatic or other NENs. The latter requires total-body 68Ga-DOTA-peptides PET/CT. Its major advantage is to detect additional tumors with other localizat...

Hypothesis: The clinical presentation of primary hyperparathyroidism (PHPT) changed lately but we don’t know if more patients in our population have asymptomatic form of PHPT.Materials and methods: Medical records of 449 patients with PHPT who were operated in three Medical Centers (Saint-Petersburg, Russia) between Jan 2011– Jun 2018 were screened. We analyzed anthropometric data, laboratory tests (PTH, 25(OH)D, Ca, iCa, P, 24-h calciuria, ALP...

In December 2019, the outbreak of coronavirus disease (COVID-19) started in Wuhan, China1, resulting in a global pandemic. A novel coronavirus (SARS-CoV-2) was identified. The virus enters the pneumocyte through the angiotensin-converting enzyme 2 (ACE2) as a receptor2. The enzyme is widely expressed. A relationship between COVID-19 and the endocrine system occurs at multiple levels. On autopsies, infarct, edema, and neuronal degeneration with SARS-CoV ge...

Objective: Coronary heart disease (CHD) is one of the leading causes of death worldwide. According to WHO experts, one out of 4 deaths in the world is due to CHD (17.8 million people annually). Type 2 diabetes is an independent risk factor for CHD. Thrombotic complications of atherosclerosis are the main cause of death in 80% of patients with type 2 diabetes.Materials and Methods: We studied the prevalence of myocardial infarction in patients with CHD an...

Background and aims: Hypoglycemia can be a risk factor for adverse cardiovascular and cerebrovascular events. However, changes in platelets and coagulation hemostasis during hypoglycemia have not been extensively studied. The aim of this study was to assess the impact of insulin-induced hypoglycemia on the platelet activity, endothelial dysfunction and the physiological anticoagulant level in patients with DM1.Research design and methods: We studied seve...

Pituitary carcinoma (PC) is defined by the presence of pituitary tumor that is either not contiguous with the primary sellar tumor and/or has metastasized to distant sites. It is very rare and associated with poor prognosis, with a median survival of 12 months when systemic metastases are present, and 30 months when metastases are confined to the central nervous system. A 20 years-old man was first diagnosed with a nonfunctioning pituitary macroadenoma in 1981 and submitted to...