Endocrine Abstracts

Introduction: Agonist receptor-GLP1 (AR-GLP1) had demonstrated its utility in obese patients with diabetes type 2. Since August 2013 we have available in Spain a new AR-GLP1 with prandial action in a single daily dose, lixisenatide. There are different clinical trials that support its efficacy and security but the dates from real clinical practice are scarce.Aim: To analyse the efficacy and security in real clinical practice for the treatment of diabetic...

Introduction: Acromegaly is a rare, challenging disease that if not appropriately treated can lead to numerous complications. Some of the most frequent complications are cardiovascular (hypertension, secondary cardiomyopathy, arrhythmias, valvulopathies, heart failure) and metabolic (secondary diabetes, various alterations of the lipid metabolisms). Aim: The aim is to asses the impact of long-term acromegaly on the cardiovascular system and glucide and l...

Adrenocortical carcinoma (ACC) is a rare endocrine tumour with a generally poor prognosis. Mitotane is the only approved drug for treatment of advanced ACC (“palliative” setting). However, response is relatively poor with up to 20% of patients experiencing objective response (Megerle 2018). Moreover, adjuvant treatment with mitotane is frequently recommended for patients at high risk of disease recurrence after surgery (Terzolo 2007, Fassnacht 2018). Of note, mitotan...

Introduction: Unexplained weight loss is a cause for concern; it might indicate an underlying condition, usualy a catabolic state. In empty sella, the progressive loss of pituitary hormone secretion is usually a slow process, with symptoms varying from one person to another and depends on the underlying cause. Usually the weight remain relatively constant or we could have several arguments for weight gain.Case report: A 57 years old man with significant ...

Background: Two prevalent and underdiagnosed endocrine disorders are primary hyperparathyroidism and Klinefelter syndrome. The main cause of primary hyperparathyroidism is parathyroid adenoma. Less commonly multiple parathyroid hyperplasia have been described with or without genetic mutations. Klinefelter syndrome could also be seen as a genetic disorder, being a chromosomal condition. Methods: We report an uncommon association, without any family histor...

Background: Subacute thyroiditis is considered a rare form of inflammatory thyroid disease, triggered by a viral infection. The prevalence is higher in women and in the middle-aged groups. The rate of subacute thyroiditis recurrence is between 1.4% and 20%, with wide discrepancies between different studies; the relapse may occur soon after de treatment or even years after, and recent studies show an HLA-dependence.Methods: We present a case report of rec...

Introduction: SARS-Cov-2 infection challenged the appropriate management of acromegaly, because of delayed or limited admissions and treatment. Despite lack of data regarding SARS-Cov-2 infection in acromegalic patients (only one case reported to date), increased susceptibility to infection and poor prognosis might be triggered by the associated metabolic, cardiovascular and respiratory comorbidities. We report a series of acromegaly patients with a positive PCR test at their ...

Introduction: Acromegaly is a rare, complex condition that throughout its evolution affects the body on numerous levels, especially if inappropriately managed. Some of the complications it develops over time are ophthalmic, neurological and psychiatric.Aim: The aim is to asses the impact of long-term acromegaly on the eye, nervous system and mental health of previously diagnosed patients.Patients and method: 90 patients’ recor...

Key learning points• Adrenocortical tumors comprise frequent benign adenomas and rare aggressive carcinomas (ACC).• cAMP/PKA pathway plays a central role in the pathogenesis of cortisol-producing adenomas - associated with Cushing syndrome, while molecular alterations in Wnt/β-catenin, Rb/p53 pathway and chromatin remodeling are frequent in ACCs.<p class="a...

The underlying basis for understanding of how brain control energy homeostasis, resides in a functional and coordinate communicating pathways between peripheral endocrine organs and the brain, in which the hypothalamus plays a pivotal role in the integration and processing of peripheral metabolic cues into satiety and feeding signals. Glial cells in particular astrocytes, as being an integral cell type of the neurovascular unit forming direct physical contacts with cerebral b...