Endocrine Abstracts

Our understanding of modifiable risk factors for developing primary hyperparathyroidism (PHPT) may support interventions to prevent the development of the disease or reduce its severity and deepen our insights into its pathogenesis. Obesity has been associated with elevated serum parathyroid hormone (PTH) in the general population and may also alter the clinical presentation in patients with PHPT.Objectives: The objectives of the study were to compare th...

Parathyroid hormone (PTH) has a biphasic effect on bone cells and can induce opposing responses resulting in both net bone loss and net bone formation. Patients with primary hyperparathyroidism (PHPT) lose the circadian rhythm for PTH and bone mass decreases. PTH administered intermittently resulting in increase in bone mass. We studied the differences in the circadian variability of bone turnover markers between women with PHPT and women with postmenopausal osteoporosis treat...

Chronic elevation of plasma glucocorticoids adversely affects cognitive processes and the structural and functional integrity of the hippocampus. Crucially, inter-individual differences in memory with ageing directly associate with blood glucocorticoid levels in rodents and humans; indeed higher plasma corticosterone in mid-life in rodents predict subsequent memory impairments. However, although keeping glucocorticoid levels low by adrenalectomy in adult life prevents the emer...

There are few valid data that describe the frequency of comorbidity in primary hypothyroidism patients seen in family practice. This study aimed to investigate the prevalence of comorbidities and their association with elevated (≥4.0%) thyroid-stimulating hormone (TSH) using a large sample of hyhpothyroidism patients from primary care practices.Materials and methods: A cross-sectional study in which multivariate logistic regression was applied to e...

Polymorphism of the vitamin D receptor (VDR) gene has been reported to play a major role in variations for genetic regulation of bone mass. The current study is an attempt to examine the association of these variations with osteoporosis in patients with hypothyroidism. The purpose of this study was to determine distribution of genotypes and allelic frequencies of polymorphism of rs731236 (C+61968t; TaqI) VDR gene, and also risk of development and association with risk factors ...

There is increasing interest in the role of vitamin D deficiency in a number of chronic health problems including autoimmune diseases. The aetiology and pathogenesis of most autoimmune disorders remain obscure and a number of factors have been implicated in their pathogenesis, one of the most recent agents found to be associated with autoimmunity is vitamin 25(OH)D. The aim of the study was to assess total vitamin 25(OH)D status in patients with autoimmune thyroiditis with sub...

Background: Metformin is the most widely used oral antihyperglycaemic drug, but it may lower B12 status, which could have important clinical implications.Aim: To study serum Vitamin B12 levels in patients with type 2 diabetes mellitus who were receiving metformin and compared them to those never treated with metformin.Materials and methods: A total of 60 patients with type 2 DM (group 1, n = 35, r...

Ubiquitin (Ub) plays a critical role in many fundamental processes like cell cycle, apoptosis, DNA repair or endocytosis. In these processes Ub acts as a signalling component able to trigger molecular events in cells. Ub does so by operating as a reversible and highly versatile regulatory signal for an expanding number of Ub-binding domains (UBD) present in cellular proteins that convey Ub signals into appropriate cellular phenotypes. In addition, it is becoming apparent that ...

Background: Over the past decade, numerous non-skeletal diseases have been reported to be associated with vitamin D deficiency including autoimmune thyroid pathology.Aim: The aim of the study is to evaluate the effects of vitamin D supplementation on insulin resistance in hypothyroidism.Materials and methods: Forty-seven participants, 32–74 years old, including 39 women (82.9%) and 8 men (17.1%) took part in the study. Serum T...

Background and aimVitamin D may affect glucose homeostasis, vitamin D levels having been found to be inversely related to glycosylated hemoglobin (HbA1c) levels in type 2 DM. With the scarcity of the regarding data in Ukraine, the aim of this study was to assess the relationship between hypovitaminosis D and glycemic control in type 2 DM women of reproductive age.Material and methodsTo test the hypothesis tha...