Endocrine Abstracts

Introduction: Osteoporosis is a serious problem all over the world. The presence of low-energy fractures increases the risk of repeated fractures twice. Each new fracture increases the risk of a fatal outcome in the future. Globally, the most effective model of re-fractures preventing in patients with osteoporosis is a Fracture Liaison Service (FLS). FLS main objectives are identification of patients, assessment of re-fractures risks, diagnosis and initiation of osteoporosis t...

Introduction: Up to 70% of adults living with human immunodeficiency virus (HIV) have excessive weight due to side effects of antiretroviral therapy (ART). Liraglutide is a licenced GLP-1 receptor agonist for the treatment of obesity in adolescents. However, there are no studies on effectiveness and safety of GLP-1 receptor agonists in patients on ART as these patients are excluded from most of the clinical trials. Herein, we present a teenage girl with HIV who developed throm...

Introduction: Pseudohypoparathyroidism (PHP) is a group of heterogeneous disorders causing parathyroid hormone (PTH) resistance. The features could include Albright’s hereditary osteodystrophy phenotype (AHO) [brachydactyly, short stature, obesity, round face, ectopic ossifications, intellectual disability]. The condition is rare with an estimated prevalence of 0.34-1.1 in 100,000 and the clinical presentation can be variable. Herein, we present 8 patients with PHP from t...

Introduction: Evaluating hunger and hyperphagia is an important component of assessing children and young people with obesity. Identifying increased hunger levels will help clinicians and health professionals to taper management aspects including relevant genetic testing and providing tailored dietary and pharmacological management.Aim: The aim of this study was to evaluate the baseline hunger levels in a group of UK adolescents with severe obesity.<...

Introduction: Visceral body fat has been shown to correlate with complications related to obesity. Body mass index (BMI) is widely used to define obesity in the adolescent population; however, it does not take the overall body composition into account. We present body composition data in a group of UK adolescents attending the tertiary MDT weight management service.Methods: Data was collected on 31 patients (M:F = 15:16) attending the MDT service over a ...

Introduction: Childhood obesity is associated with several complications related to physical and mental health. Determining health-related quality of life (HRQOL) is an important outcome measure to ensure patients receive the appropriate care.Aim: We report the baseline HRQOL in a group of UK children and adolescents with severe obesity who were managed in a Tier 3 weight management service.Methods: Paediatric quality of life (Peds...

Purpose: To assess the level of biomarkers of early kidney damage (urinary and plasma cystatin C) in patients with prediabetes and to characterize their association with risk factors for the development of nephropathy.Materials and methods: The object of the study were 60 patients (32% men, 68% women) with early disorders of carbohydrate metabolism (impaired fasting glycemia (IFG) and impaired carbohydrate tolerance (IGT), WHO criteria, 2009). The mean a...

Purpose: To study the frequency of polymorphic alleles and genotypes of the PPARG (rs 1801282) gene and its effect on carbohydrate and lipid metabolism in patients with prediabetes.Materials and methods: The object of the study were 60 patients (32% men, 68% women) with early disorders of carbohydrate metabolism (WHO criteria, 2009). The mean age was 44.3 &pm; 7.8 years. The average value of fasting glycemia - 5.7&pm;0.42 mmol/l, the average level of gly...

Using pharmacological chaperones is one of the most common area to rescue trapped proteins from Endoplasmic reticulum (ER) or Golgi apparatus as therapeutic targets in research of some endocrine disorders. Diabetes insipidus is one of these disorders and AVPR2 is seen mostly mutated in hereditary type of the disorder. As proteins go through a journey from ribosome till the place where they function at, AVPR2 also tracks the same way as a G-protein coupled receptor. A mutation ...

Nefrojenic Diabetes insipidus is one of the typical conformational disorders result from protein misfolding and degredation or aggregation due to the mutations in AVPR2. The patients of nephrogenic Diabetes insipidus have difficulty in concentrate of urine and because of this, they have polyuria, hypoosmolar urine and hypernatremia in variable levels. To make them relieved, many treatment strategies have been studying and using dDAVP nasally is one of these strategies. Another...