Endocrine Abstracts

Bilateral cervical exploration has been the gold standard in parathyroid surgery. Nowadays, the preoperative localization procedures have facilitated the minimally invasive surgery. This study aims to analyze the influence of thyroid disease in Tc99m-sestamibi scintigraphy (MIBI) results.A series of 154 patients with PHP who underwent parathyroidectomy was reviewed. Patients were divided into two groups: group 1 (G1, 58 patients) with thyroid diseases, a...

Background: There is an increasingly aware of strong associations between obesity and attention-deficit/hyperactivity disorder (ADHD), with high rates of ADHD (26–61%) in patients seeking weight loss. Psychological evaluation is mandatory in patients presenting for bariatric surgery (BS), although it is focused on eating disorders and depression, with data lacking on ADHD. ADHD could increase the risk for less successful results after surgery because of noncompliance with...

Introduction: The differential diagnosis of overgrowth includes constitutional tall stature, excess growth hormone (GH) and genetic syndromes. Sotos syndrome generally presents with overgrowth, dysmorphisms and early learning disabilities. Here in, we describe the diagnostic pathway of Sotos Syndrome in an adult male presenting with tall stature and mild morphological and cognitive features, prompted by his son’s clear manifestation of the classic triad.<p class="abst...

Just before the turning of the 20th century a detailed series of connected events led to the understanding of the physiology, pathophysiology, chemical synthesis, cellular and molecular biology, and pharmacological use of parathyroid hormone (PTH) in the next 120 years. Thanks to scientists like Fuller Albright, Gerald D. Aurbach, John T. Potts, Karen K. Winer, Thomas J. Gardella, and many others, huge progress has been made over the decades through biotechnological advances t...

Rare skeletal metabolic diseases comprise a group of diseases commonly associated with severe clinical consequences. In recent years, the description of the clinical phenotypes and radiographic features of several genetic bone disorders was paralleled by the discovery of key molecular pathways involved in the regulation of bone and mineral metabolism. Including this information in the description and classification of rare skeletal diseases may improve the recognition and mana...

Inguinal subcutaneous fat, the site of murine mammary glands 4 and 5, is a suitable model of mammary white fat adipose tissue (WAT). WAT requires extracellular Ca2+ influx for differentiation and expansion; this primarily occurs via plasma membrane Ca2+ voltage-dependent channels (CaVs). Whereas the neuropeptide oxytocin can mobilise intracellular Ca2+ in WAT which has key roles in lactation. Our aim was to use a combination of molecular biolog...

Introduction: The main purpose of this case is to present a case in which the left kurtosis interval of the fertile phase curve, may be evaluated by cheeking the biophysical changing pattern of reproducible methods of viscoelasticity and transparency of the cervical secretion.Case report: This case report included a 24 years old woman who plots a curve in which integrates two biomarkers in relation to the fertile window at the follicular phase. It was re...

Introduction: Our group has a bank of human primary thyroid cultures (BANTTIC) obtained from patients. All are individual cultures specifically genotyped and phenotyped. We believe of great interest the search for biomarkers in these cultures using differential proteomic analysis.We have applied differential proteomics using 2D-PAGE coupled to MALDI-TOF-TOF-MS. We have compared benign pathologies (normal thyroid and Pendred’s syndrome) and different...

Introduction: The Neuroendocrine Tumors Study Group of the Portuguese Endocrine Society (SPEDM) performed the first observational study between November 2012 and July 2014 too assess the profile of Gastroenteropancreatic Neuroendocrine Tumours (GEP-NET) patients (pts) followed at the main Portuguese hospitals. Several demographic and clinical data were collectedObjective: Characterize the clinicopathological features and treatment of patients with NET or...

Amyloid beta (Aβ) plaques represent one of the classic hallmarks of Alzheimer’s disease (AD) pathology in the brain. In rhesus macaques, these plaques start becoming prominent when the animals are 20+ years old, although the underlying cause(s) are unclear. In the present study, our goal was to test the hypothesis that exposure to a Western-style, high-fat, high-sugar diet (WSD) and/or loss of ovarian steroids would advance the development of this histological marker...