Endocrine Abstracts

Introduction and objectives: The cyclin-dependent kinases CDK4 and CDK6 are key regulators of the cell cycle entry, by phosphorylating the onco-suppressor retinoblastoma protein (pRb). CDK4/6 inhibitors (CDK4i) are already established as standard first-line treatment against advanced Estrogen Receptor-positive breast tumors, and have emerged as novel drugs to treat various pRb-proficient chemotherapy-resistant cancers. Presence of activating T172-phosphorylation of CDK4 in bre...

Introduction: Acromegaly usually results from GH hypersecretion elaborated by somatotrop adenoma. The occurrence of a pregnancy in an acromegaly is an infrequent event, but better described in recent years. It could be aggravate GH secretion and tumor volume.Objective: Describe eight pregnancies including twin pregnancy in six acromegalics patients hospitalized in the endocrinology department of the Pierre and Marie Curie center in Algiers.<p class="...

The vitamin D endocrine system (D-endo) is essential for calcium and bone homeostasis. The vitamin D receptor, VDR, is ubiquitously expressed and about 3% of the mouse or human genome is regulated by D-endo. VDR knock-out mice show impaired striated muscle maturation and selective VDR deficiency in heart muscle cause cardiomyopathy. Muscle weakness may be severe in patients with severe chronic renal failure combined with vitamin D deficiency or in subjects with congenital CYP2...

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Experimental studies have shown that GH and IGFs stimulate cell mutagenesis and proliferation. Moreover, an association between high-normal serum IGF-I levels and an increased risk of malignancies has been suggested in the general population. Bearing this relationship in mind, the question raises whether patients with GH deficiency (GHD) replaced with GH are at increased risk of developing malignancies and whether some patients, particularly cancer survivors, are more prone to...

The vitamin D endocrine system (D-endo) is essential for calcium and bone homeostasis. Absence of a functional VDR or CYP27B1 creates a severe rachitic bone and growth plate phenotype in humans and mice as in severe vitamin D deficiency. The intestine is the key target for VDR as a high calcium intake or selective VDR rescue in the intestine restores a normal bone and growth plate phenotype. Selective absence of VDR in osteoblasts does not create a bone phenotype when calcium ...

The immune microenvironment plays a central but ambivalent role in tumourigenesis. During initial phases of neoplasia, both innate and adaptive immune cells recognize and destroy tumour cells. However, during the process of immunoediting, tumour cells progressively reshape the microenvironment and use immune cells to favour neoangiogenesis, tumour growth and metastasis. Until recently, the role of immune response in the pathogenesis of ACC had remained elusive. Analysis of the...

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There is currently no curative treatment for metastatic phaeochromocytoma (PH) and paraganglioma (PG). Patient management aims at reducing tumor burden and preventing mechanical and secretory consequences of metastatic spread and must be adapted to disease progression. Focal treatments (surgery, radiofrequency ablation and embolization) reduce hypersecretion and facilitate subsequent systemic therapies using radionuclides (131I-MIBG, 177Lu- or 90Y-DOTATOC), chemotherapy (cyclo...

The adrenal cortex arises from the adrenogonadal primordium, which is also involved in the formation of the gonadal anlagen and is characterized by expression of the nuclear receptor Sf1. After individualisation, the adrenal primordium undergoes a series of developmental events that culminate with establishment of functional zonation, characterised by differentiation of zona glomerulosa and zona fasciculata. In the past 7 years, we have developed a number of mouse models recap...