Endocrine Abstracts

Background: TMEM127 encodes for a ubiquitously expressed transmembrane protein with limited knowledge into its role. TMEM127 germline loss-of-function is a driver of pheochromocytoma and paraganglioma (PPGLs), tumors derived from the adrenal medulla and extra-adrenal paraganglia, respectively. Molecularly, TMEM127 mutant PPGLs belong to the kinase cluster, characterized by kinase signaling transcriptional programs. Receptor tyrosine kinase RET, a driver of PPGLs via germline o...

Mattew Dobson (1735–1784) was a Liverpool physician who was recognised with FRS for his numerous and varied publications. He investigated a patient with diabetes, which at the time was considered to be a kidney disorder, associated with excessive sweet tasting urine. His experiments showed that the sweet urine, on evaporation, contained white granular material indistinguishable from sugar. However, he also made the crucial observation that the blood serum was also sweet t...

25–30% of normotensive people have salt-sensitive blood pressure, which is an independent risk factor for cardiovascular mortality. The underlying mechanisms are not clear but impaired renal salt excretion and vascular (endothelial) dysfunction are currently viewed as important processes for salt-sensitivity.To add complexity, non-modulation of the hierarchical control systems that regulate renal and vascular function are critical to the development...

25–30% of normotensive people have salt-sensitive blood pressure, which is an independent risk factor for cardiovascular mortality. The underlying mechanisms are not clear but impaired renal salt excretion and vascular (endothelial) dysfunction are currently viewed as important processes for salt-sensitivity.To add complexity, non-modulation of the hierarchical control systems that regulate renal and vascular function are critical to the development...

Within any scientific career there is one constant… change. Moving from PhD through to postdoctoral positions we have to constantly evolve to establish ourselves as independent researchers with our own unique research area and group. Academia poses several challenges for early career scientists including obtaining fellowships in an ever increasingly competitive environment, grant funding running out and short term contracts making it difficult to plan life events. Whilst...

Engaging with the public is becoming a key part of any research career and enables us to share our passion for endocrine research with the world, show how charity and government funding for endocrinology leads to new treatments and encourages the next generation of endocrine researchers. Whilst as researchers we are used to presenting our research at conferences and networking with our peers, engaging with the public about our research can be a daunting prospect. This talk wil...

We have recently observed that the peroxisome proliferator receptor α was expressed by normal and tumoural pituitary tissues, in particular by somatotrophs. To elucidate its function, we have studied the effects of fenofibrate on cell proliferation and GH secretion in GH3 cells.Material and methods: GH3 cells were grown in Ham’s F10 and treated for 24, 48 and 72 h by different concentrations of fenofibrate (12.5–50 &#...

The aryl hydrocarbon receptor interacting protein gene has been mainly involved in the pathogenesis of GH/PRL-secreting pituitary adenomas (PA). We wished to study the significance of AIP expression in clinically non-functioning PA (NFPA).Material and methods: 48 NFPA -27 gonadotroph (GnPA), 21 null cell (ncPA) – were studied for AIP, βFSH and cyclin D1 expression by real-time RT-PCR (qRT), compared with four normal post-mortem pituitaries (NP)...

Background: Graves’ disease (GD) female patients in remission after a full course of methimazole (MMI) therapy are at risk for a relapse of hyperthyroidism during the post-partum (PP) period, but whether this relapse may display any peculiarity is still unknown.Aim: To compare GD patients undergoing a relapse of hyperthyroidism either in the PP period or not.Subjects and methods: Fourty-three female patients of childbearing ag...

Introduction: We sought to the impact of an out of hours telephone advice service for children and young people with diabetes mellitus on Emergency Department attendance rates.Methods: In July 2014 we commenced a collaborative service for 240 patients with diabetes across two Paediatric diabetes centres- Croydon University Hospital (CUH) and St George’s University Hospital, London. Paediatric diabetes specialist nurses and consultants in Paediatric ...