Endocrine Abstracts

Background and aims: Neuroactive steroids and their metabolites play an important regulatory role in the nervous system affecting the neuronal plasticity, stress response, learning, and memory. The aim of the study was to compare the steroid metabolome in AD patients and controls.Materials and methods: The study comprised of 48 AD patients (30 women and 18 men; age 73.8±9.54 years) and 33 matched controls (22 women and 11 men; age 68.2±5.94 yea...

The 19th century saw the emergence of an extraordinarily gifted group of Dublin doctors who enjoy eponymous recognition. Immediately on graduating Robert Graves’ travelled for over 2 years to many of the foremost medical centres in Europe. On his return he introduced formal bedside teaching and daily lectures which has become the model for clinical training in these islands. Graves’ main other interest was the treatment of febrile illness recognizing the importance o...

The 19th century saw the emergence of an extraordinarily gifted group of Dublin doctors who enjoy eponymous recognition. Immediately on graduating Robert Graves’ travelled for over 2 years to many of the foremost medical centres in Europe. On his return he introduced formal bedside teaching and daily lectures which has become the model for clinical training in these islands. Graves’ main other interest was the treatment of febrile illness recognizing the importance o...

Robert McLachlanProfessor Robert McLachlan, FRACP, PhD is a Principal Research Fellow of the Australian NH&MRC and Director of Clinical Research at Prince Henry’s Institute of Medical Research in Melbourne, Australia. His interests include male reproductive endocrinology and the evaluation and management of male infertility, and androgen physiology. He is Deputy Director of Endocrinolog...

Robert Semple is a Reader in Endocrinology and Metabolism and Honorary Consultant Endocrinologist at the University of Cambridge, UK. He read Biochemistry and then Medicine at the University of Cambridge before internal medical posts in London. He returned to Cambridge for specialist training in Diabetes and Endocrinology, interrupted by doctoral studies with Prof. Sir Stephen O’Rahilly, focussing on transcriptio...

The European Journal of Endocrinology Prize is awarded to a candidate who has contributed significantly to the advancement of the knowledge in the field of endocrinology through publication. Further information on the prize can be found at http://www.ese-hormones.org/prizes/eje.aspx. This year’s recipient is Dr Robert Semple. The prize will be presented as part of the ECE 2015 opening ceremony where Dr Sem...

The hypothalamus integrates the neuroendocrine control of numerous hormonal systems. Energy balance is regulated by a complex neuroendocrine feedback loop, in which the ventromedial hypothalamus (VMH) responds peripheral neural and hormonal afferent signals of satiety and energy reserve (through insulin and leptin), interprets these as anorexigenic (a-MSH) or orexigenic (NPY, AgRP) signals (through the melanocortin-4 receptor), and then directs efferent autonomic signals (symp...

Our understanding of endocrine adaptation to exercise is underpinned by studies which demonstrated a causative link between low energy availability, hypothalamic-pituitary-adrenal (HPA) axis activation and hypothalamic-pituitary-gonadal (HPG) axis suppression. These and myriad other effects have been observed in elite athletes, termed Relative Energy Deficiency in Sport (RED-S), whereby negative hormonal and metabolic ramifications of exercise can be mitigated by increasing th...

The adverse effect of childhood cancer and treatment thereof on growth was firmly established in the mid-1970’s. The impact on growth is multifactorial, however, cranial irradiation was quickly established as one of the most important contributors. Exposure of the hypothalamo-pituitary (HP) region to radiation in childhood cancer survivors is now a well-established risk factor for the development of anterior hypopituitarism. The degree of hypopituitarism can vary between ...

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