Endocrine Abstracts

Beta-blockers (BB) may be less effective than other antihypertensive drugs for stroke prevention in patients with primary hypertension (ASCOT and LIFE studies). Our study compares arterial stiffness and central PP between users (BB+) and non users of BB (BB-), among menopausal women with hypercholesterolemia and no history of CV disease.Methods and Results: We used the baseline data of 664 menopausal women, screened for the Cashmere study, a12-month doub...

Premature ovarian failure or primary ovarian insufficiency (POI) is characterized by amenorrhea occurring before the age of 40-year-old, with elevated gonadotropins (FSH >20 mIU/ml). It affects 1–2% of women. So far, in more than 75% of cases, its etiology remains unknown.The obvious causes are chemotherapy, radiotherapy and ovarian surgery, mainly for bilateral ovarian endometriomas. Genetic causes of POI include rare diseases, such as blepharo...

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Adrenal infarction is usually associated with bilateral adrenal hemorrhage in the setting of antiphospholipid syndrome or hemodynamic variation. A few cases of unilateral non-hemorrhagic adrenal infarction (NHAI) have been described in the literature. Here, we report a case of unilateral non-haemorrhagic adrenal infarction occurring during pregnancy and a literature review of this clinical entity. A 30-year-old woman presented at 32 weeks of gestation with sudden-onset right a...

Introduction: Turner syndrome (TS) is a chromosomal aberration with a total or partial loss of one of the two X chromosomes, occurring in 1/2000–1/2500 newborn girls. Primary ovarian insufficiency is a classic feature of this syndrome. Therefore, fertility preservation is proposed to girls or adolescents with TS. So far, no pregnancy has been reported in TS women after ovarian or oocyte freezing. The aim of our study was to evaluate the prevalence and the outcome of spont...

Human 3β-hydroxysteroid dehydrogenase deficiency is a rare form of congenital adrenal hyperplasia resulting from HSD3B2 gene mutations, leading to steroidogenesis impairment in both adrenals and gonads. The transition period is important for a successful adult fertility, but information about fertility is lacking in this rare disease.The patient presented with salt wasting at birth in Trousseau Hospital. Consanguinity was present, since the parents ...

Illicit expression of membrane receptors for circulating regulatory factors, such as gastric inhibitory polypeptide (GIP), luteinizing hormone (LH) and serotonin (5-HT) receptors, has been well documented in ACTH-independent macronodular adrenal hyperplasias (AIMAHs) causing Cushing’s syndrome. In addition, we have observed an abnormal expression of ACTH in some steroidogenic cells in two AIMAH tissues. The aim of the present study was to investigate the role of local pro...

Common carotid artery intima media thickness (CCA-IMT), aortic stiffness (carotid-femoral pulse wave velocity-PWV) and central pulse pressure (PP) are early markers of atherosclerosis. The influence of hormonal replacement treatment (HRT) on arterial parameters in menopausal women remains to be investigated.We used baseline data of 665 menopausal women with hypercholesterolemia, screened for the CASHMERE study, a 12-month double-blind randomized trial co...

Context: Ectopic GHRH secretion is a rare cause of acromegaly described mainly in isolated case reports.Setting: From the registry of the sole laboratory performing plasma GHRH assays in France, we identified cases of ectopic GHRH secretion presenting with acromegaly between 1983 and 2008.Patients: In total, 21 patients aged 14–77 years, from 12 French hospitals. Median GHRH was 548 ng/l (270–9779)....

Background: Radioactive iodine therapy (RAI) is a classical therapeutic approach in patients with differentiated thyroid carcinoma (DCT). Few data are currently available on RAI’s potential impacts on testicular function.Design: A longitudinal prospective multi-center study (PHRC N°P040419) included male patients before a single radioiodine dose of 3.7 GBq of I 131 (V0), at 3 months (V3) and 13 months (V13) post treatment.<p clas...