Endocrine Abstracts

Primary amenorrhea is a rare disease that affects <1% of adolescent girls. The most common causes of primary amenorrhea include chromosomal abnormalities, hypothalamic and pituitary disorders, lack or structural abnormality of reproductive organs.18 years old woman was referred to us by her pediatric physician for evaluation of primary amenorrhea and hirsutism. She had low birth weight, 1.9 kg, and hypostaturism. At the age of 6 years underwent to cl...

Adrenal masses are among the most prevalent human tumors and are frequently detected unexpectedly by imaging studies performed for reasons unrelated to suspect of adrenal diseases.Subclinical hypercortisolism (SH) is the most frequent endocrine dysfunction detected in patients with adrenal incidentalomas (AI), accounting from five to 20% of all cases depending on inclusion criteria. one mg overnight dexamethasone suppression test (one mg DST) should be t...

Since earlier publications revealed a prominent and versatile impact of the neuromedin peptide family on several neuroendocrine processes, in the present experiments we focused on the effects of a recently discovered member of neuromedines, neuromedine S on such phenomena as open-field behaviour and hypothalamic-pituitary-adrenal (HPA) activation. The peptide was administered intracerebroventricularly to freely moving rats and 30 minutes later the aforementioned neuronedocrine...

Hypocalcemic cardiomyopathy due to hypoparathyroidism is a very rare condition which responds favorably to vitaminocalcic treatment.We report the case of a 50 years old man who presented to our unit for general fatigue, apathy and cough lasting several years with a worsening during the last months, there was biological evidence of hypoparathyroidism with profound hypocalcemia (21 mg/l) hyperphosphoremia (53 mg/l) and undetectable PTH levels the CT scan s...

Numerous clinical manifestations have been described in association with Cushing’s disease (CD). There was no eligible data on pulmonary function tests in CD patients. We aimed to assess pulmonary function test included spirometry in a series of patients with active Cushing’s disease (2 men, 9 women). Mean age, height, weight, body mass index were 36.7±12.6 (range 22–63 years), 156.9±8.4 cm, 74.1±10.7 kg, 29.6±3.8 kg/m2, respective...

Hypoglycaemia, a life threatening complication, occurs as part of a wide variety of disease processes. Though a common side effect of diabetes medications, it can be secondary to other factors including, endocrine and, metabolic disorders, severe sepsis, rare malignancies and non-diabetic medications. We present a case series of 3 non-diabetic patients who presented to Princess of Wales, Bridgend with Hypoglycaemic Episodes (HE):1. 23 year old student nu...

Thyroid cancer (TC) is one of the most frequent neoplasia diagnosed in general population with an estimated incidence of 6.6 cases per 100.000 and mortality of 0.43 cases per 100.000. Differentiated thyroid cancer (DTC), which includes papillary (PTC) and follicular cancer (FTC), comprises the large majority (up to 90%) of all thyroid cancer cases. At the moment etiology of TC is not completely understood, with multiple genetic and epigenetic factor that are thought to be impo...

Introduction: Prostate carcinoma is a recognised yet rare cause of Cushing’s syndrome. This report describes two cases in which Cushing’s syndrome was associated with advanced prostate cancer.Case 1: A 70-year man presented with a very short history of swelling of his face and legs. He was known to have prostate adenocarcinoma with bony metastases. He was hypokalaemic and resistant to standard potassium replacement. He had a Cushingoid appearan...

Pituitary disorders are relatively uncommon conditions which leave patients feeling isolated and distressed. Acromegaly and Cushing’s are associated with obvious and visible differences to appearance, while other pituitary conditions are associated with profound, yet hidden, physical changes which impact significantly on psychological well being.AimTo explore the subjective experiences of patients living with and managing a pi...

Background: The general population trend shows an increase in the elderly. The most affected systems in the aging process are the endocrine and cardiovascular systems. The cardiovascular conditions are very important among the diseases of the elderly, the mortality due to cardiovascular diseases holding the first place in geriatrics.The aim of the study is to determine the peculiar aspect of dehydroepiandrosterone sulfate secretion dynamics in the elderl...