Endocrine Abstracts

Background: Clinical predictors of survival of radioiodine-refractory differentiated thyroid cancer (RR-DTC) are poorly described. Age has been identified as a major prognostic factor in differentiated thyroid cancer. We asked whether age was a valuable predictor of poor prognosis in RR-DTC.Patients and method: This single centre, retrospective study enrolled all patients diagnosed with a RR-DTC between 1991 and 2017. The primary end point was overall su...

Introduction: Sulphonylureas (SU) are an effective therapy for type 2 diabetes (T2DM). As insulin secretagogues, hypoglycemia is a potencial adverse effect. Hypoglycemia may cause neuroglycopenic brain injury, which can mimetize stroke and infections of the central nervous system. Case ReportThe authors report the case of an autonomous 71 year-old woman, with medical history of hypertension and T2DM, treated with enalapril and gliclazide, that was admitted in the Emergency Roo...

Introduction: Maturity-Onset Diabetes of the Young (MODY) is a rare cause of Diabetes Mellitus (<5%), resulting from autosomal dominant monogenic defects.NEUROD1 gene is expressed in pancreatic and neuronal cells, being associated with MODY type 6. Mutations in NEUROD1 gene are reported in 20 families worldwide to date. Heterozygous variant c.616C>A, p.(His206Asn) has never been described.Case Report: The authors report a c...

About one in six hospital admissions are for a primary diagnosis of gastrointestinal (GI) disease in the UK, according to the British Society of Gastroenterology, and there is a similar incidence of disease in other developed countries. Inflammatory disease of the gut, in particular, alters the release of cytokines and gut hormones. Medication is used to manage GI diseases and endoscopies help visually monitor its progression. However, this procedure is invasive and causes dis...

Introduction: Calcitonin (CT) is the most specific marker for medullary thyroid carcinoma (MTC), thus, even low detectable values can conceal persistent disease. Current guidelines suggest performing an early CT evaluation three months after surgery. However, this timing may be too premature to evaluate the CT nadir, since different isoforms or aggregates from tumour deposits may persist in the bloodstream and require additional time to be cleared. The present study aimed to e...

Introduction: Indeterminate cytology still puzzles clinicians, due to its wide range of oncological risks. The new Italian cytological classification introduced in 2014 by SIAPEC-IAP split this category into TIR3A and TIR3B, according to a different cancer risk of <10% and <30%, respectively. Consequently, TIR3B nodules still have a surgical indication, even if more than half of cases will not result in thyroid cancer. The present study aims to analyse a consecutive se...

Introduction: Graves disease (GD) is a frequent cause of primary hyperthyroidism and often presents with weight loss. Weight gain beyond the premorbid state is often reported and could be a challenge during patient’s management. Treatment modalities, disease remission and biochemical parameters at the diagnosis have been described as predictors of weight changes in patients with GD. Objectives: To evaluate the determinants of weight changes in GD tr...

Introduction: Amiodarone is a well-established antiarrhythmic drug frequently used in tachyarrhythmias. Side effects include hypothyroidism and hyperthyroidism. Extreme cases such as myxedematous and thyrotoxic crisis are very uncommon. Here we report one case of each of these presentations.Case Report no.1: A 73-year-old woman with history of atrial fibrillation under treatment with amiodarone presented to the emergency department with headache, nausea ...

Introduction: Regarding thyroid nodules, in case of follicular lesion of undetermined significance (FLUS), performing repeat fine-needle aspiration (FNA) is a common follow-up strategy. It has been suggested that a waiting period of at least 3 months between FNAs would increase the diagnostic yield. Our study aims to clarify the optimal time for repeat FNA in case of an initial FLUS result.Methods: We identified retrospectively all thyroid FNA FLUS resul...

Introduction: Increasing incidence of thyroid cancer might be a consequence of an increase detection of subclinical disease. The aim of this study was to compare the clinical and pathologic characteristics of nonincidentally discovered (NID) thyroid cancer with incidentally discovered (ID) on postoperative pathology.Methods: A retrospective medical record review of 104 patients with thyroid cancer was performed. A group I of 69 patients with NID thyroid ...