Endocrine Abstracts

The DPP4 inhibitors that increase insulin secretion by glucose dependently can also relieve insulin resistance because they improve early phage insulin secretion and prevent late hyperinsulinaemia. It also can be more effective in controlling the blood glucose because it acts synergistically with metformin by improving insulin secretory dysfunction compared TZD with metformin that has similar action mechanism. One of those is gemigliptin that was developed in this country rece...

Background: Omega-3 polyunsaturated fatty acids are found in fish oil and they have been shown to mitigate the risk of cardiovascular disease. The mechanisms of which are not only improvement of triglycerides and various lipid parameters, but also beneficial effects on arrhythmia, inflammation. There are animal experimental results that omega-3 fatty acid can improve insulin resistance related to obesity and non-alcoholic steatohepatitis. The mechanism can be activation of PPA...

Two years ago, we presented the short term 6 month results of metformin plus DPP-4 inhibitor combination therapy when we can’t reach the target below 7% of HgA1c with metformin plus pioglitazone combination that is best in terms of relieving insulin resistance in early diabetes.Switching the pioglitazone to the DPP-4 inhibitor that improves insulin secretory dysfunction can be the next useful step to attain glucose control goal and DPP-4 inhibitors ...

Recently basal insulin is the first recommended step when failed with oral medication, and adding morning NPH is one of step 1 intensive insulin treatment regimen when failed with basal insulin alone and post-lunch glucose level is high. But morning NPH or premixed insulin alone was the usual first step before basal insulin was available. When once a day morning insulin failed to reach target, next option was splitting twice a day injection. But many patients don’t agree ...

Before launching of SGL‐2 inhibitor, triple combination of TZD with metformin and DPP‐4 inhibitor was best option for delaying progression of diabetes by improving insulin resistance and secretory dysfunction. But due to side effects of TZD such as weight gain and edema, SGL‐2 inhibitor can be another option instead of TZD. So we tried to know the effect of SGLT2 inhibitor switching from TZD with triple combination therapy in type 2 diabetes. In 80 patient...

Introduction: Sarcopenia is a geriatric syndrome that causes age-related changes to muscle mass and function. Lung function is reduced in elderly patients with sarcopenia. We explored whether a mechanically assisted squat exercise improved muscle function and mass and pulmonary function in community-dwelling elderly women with or without sarcopenia.Methods: Participants were recruited via posters or the websites of regional health centers. In total, 76 c...

Abstract: Obesity is one of the well-known initiating and aggravating factor of lymphedema. BMI is typically used to define obesity, but in Asian populations, health risks are elevated at lower BMI levels and abdominal fat may be a better obesity metric. Thus, we assessed the potential association between abdominal obesity and lymphedema severity in postoperative breast cancer patients. Thirty-three women with breast cancer-related lymphedema participated in this study. Arm ci...

Introduction: Before launching of SGL¬T-2 inhibitor, triple combination of TZD with metformin and DPP¬4 inhibitor was best option for delaying progression of diabetes by improving insulin resistance and secretory dysfunction. SGLT-2 inhibitor can be used as first combination therapy with metformin, but add on to any diabetic combination will be favorable in terms of body weight and cardiovascular risk reduction, especially in long duration of diabetes with relatively...

Hypertriglyceridemia (HTG) is known to be a risk factor for cardiovascular diseases, such as atherosclerosis and hypertension. Although the association between insulin resistance (IR) and HTG has long been recognized, the causal relationship between them has not been elucidated yet. Proper understanding of the effect of IR on HTG may better start with the realization that IR implies much more than mere impairment of glucose uptake in tissues. Given that the role of insulin is ...

Before releasing of SGLT-2 inhibitor, triple combination of metformin, DPP-4 inhibitor and TZD except sulfonylurea was commonly used in our center because it could be best option for delaying progression of diabetes by improving both insulin resistance and secretory dysfunction. SGLT-2 inhibitor is commonly used and recommended as initial combination with metformin in most guidelines because of cardiovascular risk and weight reduction, but theoretically add on to above combina...