Endocrine Abstracts

The primary treatment of adrenocortical carcinoma (ACC) is surgery and the adrenolytic mitotane. In order to test the effect of everolimus, nilotinib, imatinib and zoledronic Acid/ZOL in combination with mitotane were used ACC cell line NCI-H295R, in monolayer (2D) and spheroid (3D) cell cultures. The cytotoxicity promoted by treatments was analyzed by MTS and Cell Death assays. These assays were also performed intending of use them to test drugs in tumor cell cultures from pa...

Abstract: Congenital hypogonadotropic hypogonadism (CHH) is characterized by isolated GnRH deficiency in the absence of central anatomical causes. Classically considered to be a permanent disorder, CHH reversal has been reported in up to 15% of cases. However, reversal may not always be life-long, as hypogonadism relapse can occur in a subset of patients. Criteria for reversal normalization of circulating sex steroids, and spontaneous fertility. We report a 26-yrs-old man, who...

GS, Patients have hypokalemia, metabolic alkalosis, hypomagnesemia, and hypocalciuria together with normal blood pressure. Most of the patients are clinically asymptomatic, but some patients experience seizures, muscle weakness, cramps, episodic tetany, and paresthesia. The diagnosis is usually made based on clinical features and laboratory blood test. In this study we present a young patient with persistent hypokalaemia. She feels well in herself. She denies any symptoms of h...

Pancreatic neuroendocrine tumors are rare neoplasms of this organ. The majority of them are tumors without hormonal activity. Approximately 35% of the pancreatic neuroendocrine tumors (pNETs) are functional, the most common of which is an insulinoma. We present a 57 year old lady with dyspepsia, nausea and Fe deficiency anaemia for more then a year. On examination had a epigastric mass, endoscopy was consistent with a well differentiated endocrine grade 2 tumor. Octeotide scan...

Introduction: Pheochromocytomas are rare neuroendocrine tumours from catecholamine producing chromaffin tissue of adrenal medulla that typically present with headache, palpitations, diaphoresis, and paroxysmal hypertension. Here we describe a case of pheochromocytoma presenting as haematuria. There are case reports of paraganglioma of urinary bladder with haematuria. In our case no bladder lesion was identified but close follow up is needed for recurrence and bladder involveme...

History: 72 yr. Female, Initially presented to A&E with new confusion and speech disturbance. NEWS of 7- RR 22, sats- 98% on RA, BP 162/107, HR-124, and T- 37. AMTS- 7/10. PMH: depression, previous dysphasia, Medication: Amitriptyline, Omeprazole.Investigations: FBC, UE, LFT, CRP, Cholesterol levels, urine dip Normal and CT head – normal. ECG – Sinus tachycardia. Observations improved and no obvious cause found for confusion patient was dis...

Background: Primary hyperparathyroidism during pregnancy is rare, and may present with symptoms non-specific to hypercalcaemia.Case: A 35 years old 12/40 weeks pregnant lady presented to accident and emergency department with 6 weeks history of nausea and vomiting. On admission she felt anxious with ongoing nausea and numbness all over the body. She was a mother 2-year-old with no significant past medical history. Her medication on admission were; folic ...

Background: The causes of symptomatic bradycardia/complete are multifactorial. Bradycardia/complete heart block may be drug induced, electrolyte imbalance, ischaemic heart disease, or thyroid dysfunction. Hypothyroidism and electrolyte disturbances are reversible.Objectives/aims: To dentify/find out whether thyroid function test where performed in patients presenting with bradycardia/CHB in keeping with good practice before insertion of permanent pace ma...

An overview of current understanding of bone biology. Including new innovations in therapy,bone growth and vitamin D metabolism. An update on bone health for the specialist nurse working in paediatric endocrinology....

The opportunity to study the effects of prolonged fasting is rare. In this study we recorded anthropometric, biochemical and endocrine changes during the refeeding period following a 44 day fast, and compared them with results from 16 age-, sex- and body mass index (BMI)-matched controls.The index subject took only water to drink during the fast. He lost 24.5kg changing his BMI from 29 to 21.6. He underwent careful slow refeeding for the first 4 days usi...