Endocrine Abstracts

Objective: The maintenance of healthy and functional mitochondrial network via mitochondrial quality control (QC) mechanisms, is critical throughout life to respond to physiological adaptations and stress. Due to their role in energy production, mitochondria are exposed to high amounts of reactive oxygen species making their DNA (mtDNA) particularly vulnerable to oxidative damage. Mitochondrial dysfunction causes altered QC mechanisms (i.e. altered biogenesis, dynamics, autoph...

Background and aims: The prevalence of gestational diabetes (GDM) increases worldwide with rates between 9 and 35%. The management of GDM is a labor-intensive discipline, in which the global increase in GDM prevalence poses challenges to maintain high-quality care. A valuable solution could be the organization of group education. The ELENA study therefore aimed to evaluate women’s satisfaction about (group) education and treatment, their knowledge about GDM and whether th...

Objectives: SARS CoV-2 infections have been associated with the onset of classic subacute thyroiditis (SAT) or atypical SAT, observed in 10-15% of patients hospitalized for severe COVID19 disease (COV-A-SAT) and characterized by absence of neck pain, mild thyrotoxicosis associated with non-thyroidal illness syndrome and thyroiditis-like areas which may persist in the thyroid gland up to 12 months following SARS-CoV-2 infection, despite normalization of thyroid function. Little...

Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic disease (Covid-19) is associated with the onset of thyroid dysfunction via multiple mechanisms. Patients hospitalised for severe Covid-19 disease may develop painless atypical thyroiditis coexisting with non-thyroidal illness syndrome, which determines transient thyrotoxicosis with quick restoration of euthyroidism during the following weeks. However signs of thyroiditis at ultrasound and sci...

Hurthle cell carcinoma (HCC) represents about 5% of differentiated thyroid carcinomas. When Hurtle cell represents more than 75% of cells population, the lesion can be considered a Hurthle cell tumor (HCT); it can be classify as malignant when capsular or vascular invasion is reported or if there is a perithyroid infiltration or distant metastases occur. Aim of this study was to present our own experience on the clinical and pathological features of patients (pts) affected by ...

Background: Immune checkpoint inhibitors (ICI) are an innovative oncologic therapy used in several types of solid and hematological neoplasms. This treatment enables the antitumoral immune system response and results in significant improvement of clinical outcomes and survival rate. However, endocrine related adverse effects (ERAE) have been related, with thyroid and pituitary dysfunction being the most common endocrine diseases described. An association between the surge of e...

Purpose: The purpose of our study is to compare the effectiveness of PLA and RFA procedures in the treatment of benign thyroid nodules discussing indications, techniques, complication and outcomes derived from our experience.Method and materials: Thirty-eight patients (26F; 55±14) with benign thyroid nodules were treated, 15 with PLA and 23 with RF. Nodules were classified as thy2 through two consecutive fine-needle-aspiration (FNA) and selected for...

Purpose: Our purpose was to evaluate the safety and effectiveness of a virtual needle tracking system for US-guided percutaneous RFA of benign thyroid nodules (BTN) as compared to standard RFA.Method and materials: A STARmed (Korea) 18G bipolar RF electrode was used to perform the BTN ablation procedures. A US machine (LOGIQ E9, GE Healthcare) with a low magnetic field generator was used; electromagnetic sensors, calculating their mutual position, were s...

Introduction: Amino-Bisphosphonates (N-BPs) are potent inhibitors of the bone resorption, they inhibit enzymes of the intracellular mevalonate pathway required for prenylation of different important signaling proteins. In order to study the genetic basis of the variability in therapy response we have analysed the polymorphism of farnesyl pyrophosphate-synthase (FDPS) gene in 234 postmenopausal Danish women treated with N-BPs for 1 and 2 years.Methods: Th...

Metastases in the thyroid gland are very rare and their true incidence has not been clearly established. There are few reports of metastases to this gland and most of them are not detected in clinical practice.Although detection of metastases to the thyroid gland usually indicates poor prognosis aggressive surgical and medical treatment in isolated thyroid metastases may be effective as described for renal carcinoma.Malignant melan...