Endocrine Abstracts

Introduction: The prevalence of these disorders in pregnant women is relatively high and may affect mother and foetus adversely if they are not evaluated and treated appropriately. Therefore, their diagnosis and treatment is very important. On the other signs and symptoms of thyroid disease can often be masked by the physiologic changes of pregnancy and are not found. The aim of this study was to evaluate the physiological symptoms similar to thyroid disorders and their incide...

Introduction: Sexual dysfunction could be under the influence of menopause and the changes it causes in hormone levels. The purpose of this study is to examine the correlation between serum levels of androgens and sexual function in post-menopausal women.Methods: This is a community-based, descriptive-analytical study involving 405 post-menopausal women, aged 40–65 years, who had reached menopause up to 3 years prior to the study. A multi-stage, ran...

Pembrolizumab is a monoclonal antibody (ab) that exerts antineoplastic effects by inhibiting the immunoevasive effects PD-1 grants cancer cells. It’s used to treat several forms of cancer, including melanoma and non-small cell lung cancer. Despite the promise pembrolizumab has demonstrated, it has been associated with immune-related adverse events. In this report, we describe the first case of both thyroiditis and hypophysitis occurring during active pembrolizumab t...

Objective: The aim of this study was the identification of eNOS (G894T), p22phox (−930 A/G) and apoE gene polymorphisms associated with the impact of age-dependent endocrine changes.Subjects and methods: Subjects, both genders, were recruited and classified into the three groups: (1) 100 subjects aged 55–80+ years with mild cognitive impairment (MCI) (MMSE<28); (2) 165 age-matched subjects without cognitive impairment (MMSE>...

Objective: We previously found an association between eNOS(G894T) polymorphism and components of metabolic syndrome (MetS); thus, we investigated the metabolic–endocrine changes in postmenopausal women with incipient MetS and the interaction with the polymorphisms of eNOS-G894T, p22phox-930 A/G, CETP TaqIB and ESR1 (PvuII and XbaI) genes.Methods: postmenopausal women aged between 60 and 80 years from a population-based study were classified into the...

Background: Neuroendocrine tumors (NETs) are relatively uncommon, accounting for 10 to 14 percent of all neuroendocrine neoplasms. Twelve percent to 22% of patiens are metastatic at presentation. The most frequent primary sites are the gastrointestinal tract (62–67%) and the lung (22–27%).Case presentation: We report the case of a 36-year-old female patient diagnosed with metastatic disease, with liver, lung and lymph nodes metastasis with un...