Endocrine Abstracts

The magnitude and duration of postprandial blood glucose elevations due to hydrolysis of carbohydrates are major risk factors of diabetes and coronary heart diseases. Inhibition of the key carbohydrate hydrolyzing enzymes in the small intestine suppresses postprandial blood glucose peaks and reduces chronic vascular complications in diabetic subjects. Recent reports indicate that Syzygium spp-derived oleanolic acid (OA) inhibits glucose transport in the small intestin...

Introduction: The Birt–Hogg–Dube syndrome (BHDS) is a rare autosomal dominant genodermatosis characterised by presence of at least one of the following: benign skin fibrofolliculomas, lung cysts with recurrent pneumothoraces or renal tumours. The phenotypic constellation is due to heterozygous germline mutations of the tumour suppressor gene – FLCN, located on 17p11.2, encoding a 579 aminoacid protein termed folliculin. Case reports have described endocrine tumo...

Background: Type 1 diabetes mellitus (T1DM) is the commonest paediatric endocrine disorder in Malawi. Chronic diseases such as diabetes are frequently neglected in resource limited settings. The life expectancy from diagnosis of T1DM has been reported to be as low as 1 year in parts of Sub-Saharan Africa. The true incidence of T1DM in Malawi is unknown, however diabetic-ketoacidosis (DKA) is thought to be an overlooked child killer due to misdiagnosis. Lack of investigations, ...

Background: Birt–Hogg–Dubé (BHD) syndrome has been reported to be associated with neoplastic conditions. Its association with thyroid carcinoma has been reported but remains controversial. Here we report the case of a BHD patient with a thyroid papillary carcinoma.Case report: A 47-year-old man presented with asymptomatic facial papules, which had been gradually increasing in number for 6 years. A biopsy was taken from a papule on the nose...

Case Presentation: A 41year old female with a medical history significant for depression presented to the clinic for evaluation of bilateral nipple discharge for 5 months. The patient reported that for the last 5 months she started noticing expressible nipple discharge. She reported no associated headaches, vision changes. She denies the use of vitamins, supplements, herbal remedies. No associated fatigue, changes in the shoe/ring size, heat/cold intolerance, tremors, recent w...

Case history: Birt-Hogg-Dubé syndrome (BHDS) is a rare autosomal dominant disorder caused by heterozygous pathogenic variants in the FLCN gene encoding folliculin on chromosome 17p11, first described clinically in 1975. It is a ‘hamartomatous’ disorder usually manifesting with pulmonary cysts, benign cutaneous tumours and conferring a high risk of renal malignancy. A 43 year old man had a 34 x 22 mm right adrenal nodule discov...