Endocrine Abstracts

Background: TMEM127 encodes for a ubiquitously expressed transmembrane protein with limited knowledge into its role. TMEM127 germline loss-of-function is a driver of pheochromocytoma and paraganglioma (PPGLs), tumors derived from the adrenal medulla and extra-adrenal paraganglia, respectively. Molecularly, TMEM127 mutant PPGLs belong to the kinase cluster, characterized by kinase signaling transcriptional programs. Receptor tyrosine kinase RET, a driver of PPGLs via germline o...

Introduction: Resistant hypertension(RHTN) is an increasingly prevalent clinical condition associated with target organ damage and a poor prognosis, encompassing endocrine hypertension(EH). In this report, we describe a rare case of EH complicated by the application of a cytochrome P450(CYP450) enzyme inducer, which manifested as RHTN.Case summary: A 56-year-old man with an 18-year history of hypertension and one month documented spontaneous hypokalemia(...

A 49-year-old man who has diabetes mellitus and alcoholic cirrhosis presented to the emergency department due to left upper quadrant abdominal pain and left back soreness for three days. He received sclerotherapy and endoscopic band ligation twice for gastric varices few months prior to admission. On physical examination, he had rebound tenderness at left upper abdomen. The computed tomography (CT) of abdomen revealed diffusely enlarged left adrenal gland with rim-enhanced mul...

62-year-old woman was an employee of catering service. She had progressive limb weakness, easpecially proximal part since May, 2015, with diurnal change. She had difficulties in lifting arms, holding plates steady, and knee buckling while walking, which made her quit the job. Generalized myasthenia gravis (MG) was confirmed by positive acetylcholine receptor antibody (12.8 nmol/l) and marked decremental changes in repetitive stimulation test in November, 2015. Her limb weaknes...

Primary hyperaldosteronism is a common cause of secondary hypertension. Distinguishing between the two subtypes (unilateral aldosterone-producing adenoma and bilateral idiopathic hyperaldosteronism) is crucial for patient’s management. Adrenal venous sampling is an important method for evaluation of the condition, but selective successful right adrenal venous sampling is often reported to be a difficult procedure. A retrospective review of 51 cases suffering from primary ...

Immunoglobulin G4-related disease (IgG4-RD) is a newly identified syndrome characterized by high serum IgG4 levels and increased IgG4-positive plasma cells infiltration. IgG4-related thyroiditis (IgG4-RT) was first prescribed based on the immunohistochemistry in 2009. Some of Hashimoto’s thyroiditis (HT), Graves’ disease (GD) and Riedel thyroiditis were reported to be classified as IgG4-RT based on high serum IgG4 level or histopathological findings. However, the pre...

IntroductionMultiple endocrine neoplasia type 1 (MEN-1) is a hereditary condition with neoplastic lesions in multiple endocrine organs, which most frequently involves pituitary, parathyroid gland, and pancreas.Case reportA 53 y/o male visited endocrine clinic with the chief complaint of foreneck swelling for 1 month. He had history of renal stone for years. He had normal fT4 (1.13 ng/dl, reference 0.93–1...

Introduction: Endocrine complications are common in patients with thalassaemia major. Currently, there is no literature studying the prevalence of endocrine abnormalities within a British cohort of children with transfusion-dependent thalassaemia. Existing literature is mostly based on Greek and other Mediterranean thalassaemia populations, and variations in local management guidelines may result in different clinical outcomes. This study aimed to audit recomm...

Background: This study aimed to investigate the association between the intensity of statin therapy and the development of cardiovascular disease (CVD) and diabetes in individuals without prior diabetes who were being treated for dyslipidemia with statins for the primary prevention of CVD, using the National Health Insurance Service-Health Screening (NHISHEALS) database.Methods: The database is a longitudinal cohort study of Korean men and women 40 years...

Purpose: This retrospective study is intended to determine the dose of radioactive iodine using thyroglobulin levels measured after two weeks of thyroid hormone withdrawal in patients with differentiated thyroid cancer. Methods : Patients who were diagnosed as differentiated thyroid cancer and treated with radioiodine after total thyroidectomy were enrolled. Serum thyroglobulin test (preTG; ng/dl) was performed 1 week before radioiodine treatment and 2 w...