Endocrine Abstracts

Background: The aim of our study is to show the evaluate relationship between cytological feature of thyroid nodule and TSH level.Objective: To retrospectively evaluate the usefulness of serum TSH levels as a predictor of thyroid cancer.Methods: Patients with thyroid nodule(s) who underwent fine-needle aspiration biopsy under ultrasonographic guidance in a Clinica of Administration of the President of the RF were consecutively eval...

Introduction and Objective: Thyroid cancer (TC) is the most common endocrine tumor with a growing incidence worldwide. However, diagnostics using ultrasound research methods do not allow to unambiguously determine the type of thyroid lesion and make a precise diagnosis in early stages. The results of recent studies indicate the metabolic changes occurring in cancer cells. Various molecular biomarkers and indices (TYG, TYG-BMI) may indicate the onset of development and progress...

An MDT approach to facilitating a workable transition between paediatric and adult services for young people with T1 and T2 diabetes. Management of young people with T2 diabetes is an emerging field that provides new challenges to the healthcare team in enabling young people to live with a lifelong condition that may also be affecting the wider family. Our service is delivered across two sites looking after young people with diabetes aged between 14–19 years in paediatric...

Introduction: Women prescribed hormonal therapies for breast cancer (eg Aromatase Inhibitors (AI) and ovarian suppression therapy (OST)) are at increased risk of fracture and monitoring of Bone Mineral Density (BMD) is needed. Recommendations for BMD monitoring and treatment interval thresholds differ between guidelines which has implications for management. We compared the outcomes from the application of 3 commonly used guidelines for bone health in women wi...

White adipose tissue is a vital endocrine organ required for the storage of energy in the form of triglycerides, which is released in response to nutrient deprivation, and for the production of hormones such as leptin and adiponectin. In this way, adipose tissue is at the forefront of whole organism energy homeostasis. Adipose tissue dysfunction is associated with many metabolic diseases including T2D, cardiovascular disease and non-alcoholic fatty liver disease (NAFLD). Adipo...

Introduction: The diagnosis of Turner Syndrome (TS) must be included in the differential diagnosis of all girls with short stature. Despite overall earlier diagnosisand treatment there remain patients with TS who present late with delayed puberty.Although growth hormone (GH) is known to increase final height (FH) in girls with TS, little evidence exists on treatment in late-presenting girls.Objective and hypothesis: To assess the effect of late GH treatm...

The environment has become increasingly contaminated by various pollutants including endocrine disrupting chemicals (EDCs). This has led to an increase in the incidence and gravity of known pathologies and the emergence of new ones, including dental pathologies as the Molar Incisor Hypomineralization (MIH). Among the thousands of EDCs, bisphenol A (BPA) and phthalates (DEHP) are widely used by the plastic industry and responsible to frequent contaminations. We previously showe...

There has been increasing concerns over the last 20 years about the potential adverse effects of endocrine disruptors (EDs). Anecdotally, molar incisor hypomineralization (MIH), a recently described enamel pathology, now affecting 15–18% of 6–9 years old children, is increasing concurrently with ED related pathologies. Our previous data show that bisphenol A (BPA) and vinclozolin, two anti-androgenic EDs, impact amelogenesis and enamel mineralization preferentially i...

Bisphenol A (BPA) is a widespread endocrine disruptor commonly used by plastic industries. More than 95% of the world population contains BPA (ng/ml) in biological fluids raising the question of its activity and potential adverse effects. Anecdotally, molar incisor hypomineralisation (MIH), an enamel pathology affecting 15–18% of children, is increasing concurrently with ED related pathologies. Our previous data show that BPA impacts amelogenesis and generate similar enam...

MIH (Molar Incisor Hypomineralyzation) is a recently described enamel pathology that affects now 15 to 18% of children worldwide. Its prevalence increased similarly to other pathologies associated to exposure to Endocrine Disrupting Chemicals (EDCs). In addition, MIH affects selectively permanent first molars and incisors, the first developing teeth during the perinatal period also the time window with the highest susceptibility to EDCs. Our previous published data showed the ...